Effects of Water Deprivation and Morphine Administration on Atrial Natriuretic Peptide mRNA Levels in Rat Auricles.
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概要
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We investigated the influences of two potent stimuli, water deprivation (5 days) and morphine administration (100 mg/kg), on the level of atrial natriuretic peptide (ANP) mRNA in the rat auricles. The ANP mRNA level was measured by Northern blot hybridization analysis. The plasma concentration of ANP decreased in water deprived rats, and the ANP mRNA levels in both auricles of these rats were lower than those of the control, particularly in the left auricle. Thirty minutes after the injection of morphine, the plasma concentration of ANP markedly increased, while morphine increased the right auricular ANP mRNA level 4 hr after the administration. These data suggest that these stimuli can change ANP gene expression in the auricles and that the changes are induced differentially in both auricles.
- 公益社団法人 日本薬理学会の論文
著者
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Tamaki Toshiaki
Department Of Pharmacology Kagawa Medical School
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Abe Youichi
Department Of Pharmacology Kagawa Medical University
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Nakamura Akio
Department Of Information And Computer Sciences Saitama University
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Fukui Kiyoshi
Department Of Biochemistry National Cardiovascular Center Research Institute
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Iwao Hiroshi
Department Of Cardiovascular Medicine Akita University Graduate School Of Medicine
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Nakamura Akio
Department of Pharmacology, Kagawa Medical School
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