Tissue distribution of capsaicin receptor in the various organs of rats
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概要
- 論文の詳細を見る
Capsaicin receptor (vanilloid receptor 1, VR1), a cation channel, has been recently cloned and shown to be expressed in a subset of sensory neurons (Caterina et al., 1997, Nature 389, 816-824). To examine the distribution of VR1 on the protein level in the whole body, we produced an antiserum against bacterially expressed VR1. Immunoblot analysis revealed that VR1 was expressed in not only nervous tissues including brain but tongue, esophagus, diaphragm, and leg muscle. In these tissues, VRl mRNA was also expressed (confirmed by RT-PCR). The significance of the expression in these muscles was discussed.
- 日本学士院の論文
著者
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TSUTSUMI Satoshi
Department of Neurological Surgery, Juntendo University Urayasu Hospital
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Ishikawa Ryoki
Department Of Molecular And Cellular Pharmacology Gunma University Graduate School Of Medicine
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NAKAMURA Akio
Department of Material Science, Japan Atomic Energy Research Institute
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YAO Jihong
Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University
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Yao Jihong
Department Of Clinical Pharmacology College Of Pharmacy Dalian Medical University
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KOHAMA Kazuhiro
Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine
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Tsutsumi Satoshi
Department Of Chemical Engineering Faculty Of Engineering Science Osaka University
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Kohama Kazuhiro
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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ONOZAWA Kaname
Department of Pharmacology, Gunma University School of Medicine
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Nakamura Akio
Department Of Information And Computer Sciences Saitama University
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Nakamura Akio
Detp. Mol. Cell. Pharmacol. Gunma Univ. Grad. Sch. Med.
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TSUTSUMI Satoshi
Department of Pharmacology, Gunma University School of Medicine
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KOHAMA Kazuhiro
Department of Pharmacology, Gunma University School of Medicine
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YAO Jihong
Department of Pharmacology, Gunma University School of Medicine
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