Effect of N-(N-(L-trans-3-carboxyoxirane-2-carbonyl)-L-leucyl)-3-methyl-butylamine (E64C), a thiol-protease inhibitor, on tyrosine release from skeletal muscle cells.
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概要
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Low concentrations (μg/ml level) of N-[N-(L-trans-3-carboxyoxirane- 2-carbonyl)-L-leucyl]-3-methyl-butylamine (E64C), a thiol-protease inhibitor, inhibited tyrosine release from skeletal muscle cells in which tyrosine release had been enhanced. Increase in cytoplasmic Ca2+ concentration seemed to be one of the factors that promoted the tyrosine release. These findings were discussed in relation to the mode of the protein degradation in the cells by thiolproteases including calcium-activated neutral protease.
- 日本学士院の論文
著者
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Shirao Tomoaki
Department Of Neurobiology And Behavior Gunma University Graduate School Of Medicine
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Kohama Kazuhiro
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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MITANI Shohei
Department of Pharmacology, Faculty of Medicine, The University of Tokyo
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KOHAMA Kazuhiro
Department of Pharmacology, Faculty of Medicine, University of Tokyo
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