Nicotinic Acetylcholine Receptor α7 Subunit Mediates Migration of Vascular Smooth Muscle Cells Toward Nicotine
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概要
- 論文の詳細を見る
GbaSM-4 cells, vascular smooth muscle cells (VSMCs) derived from brain basilar arteries, were shown to migrate toward d-nicotine by augmenting the actin cytoskeleton in their cell bodies and lamellipodia, and expression of nicotinic acetylcholine receptor (α7-nAChR) was detected in GbaSM-4 cells. Their chemotaxis was antagonized by an α7-nAChR antagonist of methyllycaconitine. It was also antagonized by inhibiting myosin light chain (MLC) kinase and by down-regulating MLC kinase. However, the changes in MLC phosphorylation were not associated with the nicotine treatment, suggesting the involvement of non-kinase activity of MLC kinase as reviewed by Gao et al. (IUBMB Life. 2001;51:337). This plot may work to induce arteriosclerosis during cigarette smoking.
- 2004-03-01
著者
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Tanaka Hideyuki
Department of Cardiology, Nihon University Surugadai Hospital
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NAKAMURA Akio
Department of Material Science, Japan Atomic Energy Research Institute
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Zhao Tiejun
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Nakamura Akio
Dept. Mol. Cell. Pharmacol. Gunma Univ.
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KOHAMA Kazuhiro
Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine
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Ye L‐h
Gunma Univ. Graduate School Of Medicine Gunma Jpn
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Ye Li-hong
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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LI Sheng
Department of Oral and Maxillofacial Surgery, West China College of Stomatology, Sichuan University
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Xin Hong
Department of Pharmacology, School of Pharmacy, Fudan University, China
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Xin Hong
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Zhang Xiaodong
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Kohama Kazuhiro
Dep. Of Molecular And Cellular Pharmacology Gunma Univ. Graduate School Of Medicine Jpn
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Kohama Kazuhiro
Detp. Mol. Cell. Pharmacol. Gunma Univ. Grad. Sch. Med.
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Kohama Kazuhiro
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Li Sheng
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Tanaka Hideyuki
Department Of Cardiology Nihon University Surugadai Hospital
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Li Sheng
Department Of Biochemistry Nagoya City University Medical School
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Nakamura Akio
Department Of Information And Computer Sciences Saitama University
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Nakamura Akio
Detp. Mol. Cell. Pharmacol. Gunma Univ. Grad. Sch. Med.
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Tanaka Hideyuki
Department Of Agricultural Chemistry Faculty Of Agriculture Utsunomiya University
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Tanaka Hideyuki
Department Of Health Sciences Gunma University
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YE Li-Hong
Department of Biochemistry, College of Life Sciences, Nankai University
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