Effect of Cigarette Smoke Components on Vascular Smooth Muscle Cell Migration Toward Platelet-Derived Growth Factor BB
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概要
- 論文の詳細を見る
Cigarette smoking is one of the factors causing accumulation of vascular smooth muscle cells (VSMCs) in atherosclerotic plaques. Changes in cell migration toward platelet-derived growth factor BB were investigated using a Boyden chamber after 48-h preincubation of GBaSM-4 VSMCs with nicotine or nicotine-free cigarette smoke extract (CSE). A nicotine concentration of 0.1 μM maximally promoted cell migration; 0.1% CSE also promoted cell migration, while high CSE concentrations damaged GBaSM-4 cells. Fetal bovine serum (FBS) long-depletion induced decrease in migration of GBaSM-4 cells. Our results suggest that nicotine and some CSE components can induce GBaSM-4 cell migration.
著者
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Wang Hong
Department of Oriental Medicinal Material & Processing, College of Life Science, Kyung Hee Universit
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NAKAMURA Akio
Department of Material Science, Japan Atomic Energy Research Institute
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Miwa Soichi
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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KOHAMA Kazuhiro
Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine
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Horinouchi Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Yoshiyama Shinji
Department of Molecular and Cellular Pharmacology, Gunma University Graduate School of Medicine, Jap
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Miwa Soichi
Division Of Pharmacology Department Of Biochemistry And Bioinformative Sciences School Of Medicine U
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Yoshiyama Shinji
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Kohama Kazuhiro
Department Of Molecular And Cellular Pharmacology Faculty Of Medicine Gunma University Graduate Scho
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Wang Hong
Department Of Applied Biology Faculty Of Textile Science And Technology Shinshu University
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Nakamura Akio
Department Of Information And Computer Sciences Saitama University
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Horinouchi Takahiro
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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