The β_3-Adrenoceptor-Mediated Relaxation Induced by Epinephrine in Guinea Pig Taenia Caecum
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概要
- 論文の詳細を見る
The mechanisms of the β-adrenoceptor-mediated relaxation induced by epinephrine in guinea pig taenia caecum were examined. The relaxant response to epinephrine was unaffected by propranolol(〜10^<-5>M)or phentolamine(〜10^<-5>M). The response to epinephrine was antagonized in a concentration-dependent manner by bupranolol, and Schild plot of the data revealed the pA_2 value of 5.87. Epinephrine significantly increased cyclic AMP level in this preparation. Bupranolol(10^<-4>M)significantly decreased the cyclic AMP level that was elicited by epinephrine, wereas propranolol(10^<-5>M)produced no effect. These results suggest that the relaxant response to epinephrine in the guinea pig taenai caecum is mainly mediated by β_3-adrenoceptors.
- 日本平滑筋学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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YAMAMOTO Yoshihisa
Department of Physics, Tokyo Institute of Technology
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Horinouchi Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Horinouchi Takahiro
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences Funabashi
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Horinouchi Takahiro
Department Of Cellular Pharmacology Hokkaido University Graduate School Of Medicine
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Yamamoto Yoshihisa
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences
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Yamamoto Yoshihisa
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences Funabashi
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Horinouchi Takahiro
Department Of Cellular Pharmacology Graduate School Of Medicine Hokkaido University
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Koike Katsuo
Department Of Chemical Pharmacology Toho University School Of Pharmaceutical Sciences Funabashi
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