Characterization of Subtype of Propylbenzilylcholine Mustard (PrBCM)-Sensitive and-Resistant Muscarinic Cholinoceptors in Guinea Pig Ileal Muscle.
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概要
- 論文の詳細を見る
The subtype of propylbenzilylcholine mustard (PrBCM)-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle was examined using four selective muscarinic antagonists, pirenzepine, AF-DX 116, himbacine and 4-DAMP. The pA<SUB>2</SUB> values of the four antagonists against pilocarpine were not different from their values against carbachol after the treatment with PrBCM and was identified with the values for the m3 subtype. These results suggest that the subtype of PrBCM-sensitive and -resistant muscarinic cholinoceptors in guinea pig ileal muscle is the m3 subtype only and not other subtypes.
- 公益社団法人 日本薬理学会の論文
著者
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Koike Katsuo
Department Of Chemical Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Harada Mariko
Department Of Chemistry Faculty Of Integrated Arts And Sciences The University Of Tokushima
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