EFFECTS OF ANTI-ASTHMATIC DRUGS ON AIRWAY RESISTANCE AND PLASMA LEVEL OF CYCLIC AMP IN GUINEA PIG
スポンサーリンク
概要
- 論文の詳細を見る
Effects of anti-asthmatic drugs on airway resistance and plasma level of cyclic AMP were investigated in guinea pigs sensitized and nonsensitized with egg-albumin. Histamine increased airway resistance in the both groups of guinea pigs, and guinea pigs sensitized with egg-albumin were more sensitive to histamine. Anti-asthmatic drugs inhibited dosedependently the increase of airway resistance caused by histamine. Sensitization with egg-albumin decreased the potencies of the β-adrenoceptor stimulants, salbutamol and isoprenaline, but not that of aminophylline. The plasma level of cyclic AMP was increased by salbutamol and isoprenaline, but not by aminophylline. The increased plasma level of cyclic AMP by β-adrenoceptor stimulants was not attenuated by sensitization with egg-albumin.
- 社団法人 日本薬理学会の論文
著者
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Chung Chang
Department of Nuclear Engineering, Seoul National University
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Chung Chang
Department Of Nuclear Engineering Seoul National University
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IWAYAMA Yumiko
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Iwayama Yumiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Chung Chang
Department Of Chemistry And Biochemistry Texas Tech University
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CHUNG Chang
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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