INHIBITORY ALPHA-ADRENERGIC ACTION OF PHENYLEPHRINE IN GUINEA PIG TAENIA CAECUM
スポンサーリンク
概要
- 論文の詳細を見る
Phenylephrine, a selective a-adrenergic stimulant, caused a maximal relaxation of the taenia from guinea pig caecum in the concentration of 10<SUP>-6</SUP> g/ml. Phenylephrine in this concentration did not influence intracellular cyclic AMP and cyclic GMP levels. Although phenylephrine abolished the spontaneous spike discharge, no change was detected in <SUP>45</SUP>Ca-uptake and <SUP>45</SUP>Ca-efflux on the tissue level after phenylephrine. Ca-uptake and Ca-release on the subcellular level were also not influenced by phenylephrine. In Ca free-solution phenylephrine inhibited the response to CaCl<SUB>2</SUB>. Phenylephrine increased <SUP>42</SUP>K-efflux in the normally polarized taenia and also in the K-depolarized taenia.
- 社団法人 日本薬理学会の論文
著者
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Takayanagi Issei
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(correspo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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IWAYAMA Yumiko
Department of Chemical Pharmacology, Toho University School of Pharmaceutical Sciences
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Iwayama Yumiko
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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TAKAYANAGI Issei
Department of Chemical Pharmacology, Toho University, School of Pharmaceutical Sciences
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