Effects of Calmodulin Antagonist (W-7) on Phorbol Ester (PMA)-induced Contractile Response in Isolated Rat Aorta
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概要
- 論文の詳細を見る
The aim of this study was to investigate effects of calmodulin antagonist (W-7) on the contractile response of the rat aorta induced by activation of protein kinase C (PKC) by phorbol ester. Phorbol 12-myristate 13-acetate (PMA) produced biphasic contraction i.e., a sustained contraction (initial contraction) and 17.9±1.7 min later, this progressively developed contraction was changed to a delayed contraction superimposed on the initial contraction. The delayed contraction was completely inhibited by treatment with nicardipine. The onset of the delayed contraction was significantly delayed by treatment with W-7, whereas same concentration of W-7 showed a weak relaxant effect (10%) on the PMA-induced maximal contraction of aorta. Higher concentration of W-7 strongly inhibited PMA-induced sustained contraction. These results suggest that PMA-induced biphasic contractile response may be regulated by calmodulin.
- 日本平滑筋学会の論文
著者
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KAMATA Katsuo
Department of Pharmacology, School of Pharmacy, Hoshi University
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Kamata Katsuo
Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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SUENAGA Hiroshi
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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Suenaga Hiroshi
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kasuya Yutaka
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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