Altered arachidonic acid-mediated responses in the perfused kidney of the streptozotocin-induced diabetic rat

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概要

• 論文の詳細を見る

• Using perfused kidneys isolated from age-matched controls and streptozotocin (STZ)-induced diabetic rats, we investigated the effects of arachidonic acid (AA) on perfusion pressure in the presence of methoxamine. AA elicited a transient contraction followed by a sustained relaxation in each group. The amplitude of contraction was smaller in the diabetic group than in the control group, whereas the amplitude of the sustained relaxation was greater in the former than in the latter group. In the diabetic group, the AA-induced sustained relaxation was completely inhibited by indomethacin [cyclooxygenase (COX) inhibitor], SKF525A [cytochrome P450 (CYP450) inhibitor], or clotrimazole (epoxygenase inhibitor), but not by furegrelate [thromboxane A_2 (TXA_2)-synthase inhibitor], SQ29548 (TXA_2-receptor antagonist), or baicalein [lipoxygenase (LOX) inhibitor]. In the diabetic kidney, more-or-less additive inhibitions of the AA-induced relaxation were seen when indomethacin was given with either SKF525A or clotrimazole. These results suggest that in the STZ-induced diabetic perfused kidney, vasorelaxant metabolites derived from AA (probably COX and/or CYP450 metabolites) are increased, and may serve to regulate vascular tone.

• 日本平滑筋学会の論文

著者

• Hosokawa Masao

  Department Of Gastroenterology Muroran General Hospital

• MATSUMOTO Takayuki

  Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University

• KAMATA Katsuo

  Department of Pharmacology, School of Pharmacy, Hoshi University

• Kamata K

  Dep. Of Physiology And Morphology Inst. Of Medicinal Chemistry Hoshi Univ.

• Kamata Katsuo

  Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F

• KOBAYASHI Tsuneo

  Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University

• Matsumoto Takayuki

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• Kobayashi Tsuneo

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• Matsumoto Takayuki

  Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp

• Kobayashi Tsuneo

  Department Of Physics School Of Medicine Fukushima Medical University

• Matsumoto Takayuki

  Department Of Electronics Information And Communication Engineering Waseda University

• Hosokawa Masao

  Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University

• KAMATA Katsuo

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University

• KOBAYASHI TSUNEO

  Department of Natural Sciences (Physics), School of Medicine, Fukushima Medical University

• KOBAYASHI Tsuneo

  Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo Noko University

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