Effects of anthocyanidin derivative (HK-008) on relaxation in rat perfused mesenterial bed
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概要
- 論文の詳細を見る
Anthocyanins, which are responsible for a variety of bright colors (including red, blue, and purple) in fruits, vegetables, and flowers, are consumed as dietary polyphenols. Anthocyanin-containing fruits are thought to decrease coronary heart disease and are used in anti-diabetic preparations. Diabetes is associated with a variety of cardiovascular complications that may be mediated by endothelial dysfunction, and so this study was designed mainly to characterize the influence of a synthesized anthocyanidin derivative (HK-008) over acetylcholine (ACh)-induced relaxation in mesenteric arterial beds isolated from rats. In a glucose-tolerance test in intact rats, HK-008 (30mg/kg) reduced the glucose level as effectively as the same dose of glibenclamide. The aortic relaxation induced by pinacidil (an ATP-sensitive potassium channel opener) was greatly inhibited by glibenclamide (10μM), and also significantly inhibited by HK-008 (10μM). Interestingly, the ACh-induced relaxation in the perfused, preconstricted mesenteric arterial bed was significantly enhanced by HK-008 (10μM), and this enhancement was significantly attenuated by indomethacin (10μM). The ACh-induced mesenteric relaxation was impaired by an increase in oxidative stress, viz. superoxide-generating treatment [xanthine oxidase (XO; 0.1 U/ml) plus hypoxanthine (HX; 10μM)]. However, this impairment was strongly suppressed by HK-008 (10μM). These results suggest that HK-008 increases endothelium-induced relaxation by suppressing oxidative stress or modulating prostanoids signaling. This compound may therefore be useful against certain cardiovascular disorders.
- 日本平滑筋学会の論文
著者
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MATSUMOTO Takayuki
Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University
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HONDA Toshio
Faculty of Pharmaceutical Sciences, Hoshi University
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Nishiyama Misaki
Faculty Of Pharmaceutical Sciences Hoshi University
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Honda Toshio
Faculty Of Pharmaceutical Sciences Hoshi University
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KAMATA Katsuo
Department of Pharmacology, School of Pharmacy, Hoshi University
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Kamata K
Dep. Of Physiology And Morphology Inst. Of Medicinal Chemistry Hoshi Univ.
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Kamata Katsuo
Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F
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MAKINO Ayako
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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TAGUCHI Kumiko
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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KOBAYASHI Tsuneo
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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KANIE Noriyasu
Department of Physiology and Morphology, Institute of Medicinal Chemistry
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ODA Shu-ichi
Department of Physiology and Morphology, Institute of Medicinal Chemistry
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KIKUCHI Toyohiko
Faculty of Pharmaceutical Sciences, Hoshi University
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NISHIMURA Masato
Faculty of Pharmaceutical Sciences, Hoshi University
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Oda Shu-ichi
Department Of Physiology And Morphology Institute Of Medicinal Chemistry
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Makino Ayako
Department Of Physiology And Morphology Institute Of Medicinal Chemistry
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Kanie Noriyasu
Department Of Physiology And Morphology Institute Of Medicinal Chemistry
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Matsumoto Takayuki
Department Of Gastroenterology Osaka City University Graduate Medical School
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Matsumoto Takayuki
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kikuchi Toyohiko
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kobayashi Tsuneo
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Matsumoto Takayuki
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp
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Kobayashi Tsuneo
Department Of Physics School Of Medicine Fukushima Medical University
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Matsumoto Takayuki
Department Of Electronics Information And Communication Engineering Waseda University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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KOBAYASHI TSUNEO
Department of Natural Sciences (Physics), School of Medicine, Fukushima Medical University
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KOBAYASHI Tsuneo
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo Noko University
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