Effect of phorbol 12, 13-dibutyrate on smooth muscle tone in rat stomach fundus
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概要
- 論文の詳細を見る
We investigated the effects of phorbol 12, 13-dibutyrate (PDBu), a typical protein kinase C (PKC) activator, on smooth muscle tone in the rat stomach fundus. In 5-hydroxytriptamine (5-HT)-precontracted stomach fundus strips, PDBu induced dose-dependent relaxation, but 4α-phorbol 12, 13-didecanoate, a phorbol ester that does not activate PKC, did not induce relaxation. A PDBu-induced dose-dependent relaxation was also observed in strips precontracted with platelet-activating factor (PAF), carbachol, or 60mM K^+. In stomach fundus strips pretreated with PDBu, the contractile responses to 5-HT and PAF were completely blocked, but those induced by carbachol and endothelin-1 (ET-1) were only partially inhibited. In stomach fundus strips preincubated with carbachol in Ca^<2+>-free medium, the Ca^<2+>-induced contraction was decreased by preincubation with PDBu. In strips preincubated with 5-HT, PAF, or ET-1 in Ca^<2+>-free medium, Ca^<2+>-induced contractions were greatly inhibited by pretreatment with PDBu. These results suggest that in rat stomach fundus strips, PDBu-induced relaxation is mediated by activation of PKC. We speculate that a major factor mediating the relaxant action of PDBu in rat stomach fundus smooth muscle is represented by a reduction in Ca^<2+> influx via an inhibition of Ca^<2+> channels.
- 日本平滑筋学会の論文
著者
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MATSUMOTO Takayuki
Departments of Laboratory Medicine, Ohashi and Omori Hospitals, School of Medicine, Toho University
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Nishiyama Misaki
Faculty Of Pharmaceutical Sciences Hoshi University
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KAMATA Katsuo
Department of Pharmacology, School of Pharmacy, Hoshi University
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Kamata K
Dep. Of Physiology And Morphology Inst. Of Medicinal Chemistry Hoshi Univ.
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Kamata Katsuo
Department Of Pharmacology School Of Pharmacy Hoshi University:department Of Chemical Pharmacology F
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Y
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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KOBAYASHI Tsuneo
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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NISHIYAMA Misaki
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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Matsumoto Takayuki
Department Of Gastroenterology Osaka City University Graduate Medical School
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Matsumoto Takayuki
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Kobayashi Tsuneo
Department Of Physiology And Morphology Institute Of Medicinal Chemistry Hoshi University
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Matsumoto Takayuki
Department Of Gastroenterology And Hepatology Institute Of Clinical Medicine Graduate School Of Comp
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Kobayashi Tsuneo
Department Of Physics School Of Medicine Fukushima Medical University
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Matsumoto Takayuki
Department Of Electronics Information And Communication Engineering Waseda University
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KASUYA Yutaka
Department of Physiology and Morphology, Institute of Medicinal Chemistry, Hoshi University
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KAMATA Katsuo
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, Meijo University
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KOBAYASHI TSUNEO
Department of Natural Sciences (Physics), School of Medicine, Fukushima Medical University
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KOBAYASHI Tsuneo
Department of Agricultural Chemistry, Faculty of Agriculture, Tokyo Noko University
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