ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL ADMINISTRATION OF EICOSAPENTAENOIC ACID
スポンサーリンク
概要
- 論文の詳細を見る
Chronic effects of highly purified eicosapentaenoic acid (EPA) on systolic blood pressure in spontaneously hypertensive rats (SHR) and normotensive rats were studied. Daily oral administration of 30 to 300 mg/kg EPA for eight weeks significatly decreased the development of hypertension in SHR dose-dependently. Eight weeks treatment of 30,100,and 300 mg/kg EPA reduced mean systolic blood pressure by 23,29,and 32 mmHg, respectively, compared to untreated rats. Hypotensive effect of EPA progressed slowly and was reversible after the termination of the treatment. However, daily administration of EPA to normotensive rats did not affect the systolic blood pressure. EPA may be useful as a hypotensive agent for treatment of hypertension.
- 社団法人日本薬学会の論文
著者
-
松本 直章
東京大学大学院農学生命科学研究科獣医臨床病理学教室
-
MATSUKI Norio
Department of Chemical Pharmacology,Faculty of Pharmaceutical Sciences
-
Matsuki Norio
Lab. Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Univ. Of Tokyo Jpn
-
Matsuki N
Univ. Tokyo Tokyo Jpn
-
Matsuki N
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
-
Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The Universe Of Tokyo
-
KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
-
UTSUNOMIYA NAOKO
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
-
Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences
-
Matsuki Norio
Graduate School Of Pharmaceutical Sciences The University Of Tokyo
-
Matsuki Norio
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Science The University Of Tokyo
-
Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
-
Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
-
Matsuki Norio
Laboratory Of Chemical Pharmacology Graduate School Of Pharmaceutical Sciences The University Of Tok
-
Utsunomiya Naoko
東京大学 薬
関連論文
- 低酸素下の犬の肝組織中ヌクレオチドならびにオキシプリン濃度に及ぼすハロセン麻酔の影響
- Role of microsomal triglyceride transfer protein in induction of fatty liver in suncus
- Defect in an Intrahepatic Degradation of Apolipoprotein B in Suncus: An Animal Model of Hypobetalipoproteinemia^1
- Role of Acyl Coenzyme A Cholesterol Acytransferase in Intrahepatic Processing of apo B-Lipoprotein in Suncus
- Defect in Assembly Process of Very-Low-Density Lipoprotein in Suncus Liver: An Animal Model of Fatty Liver
- Novel Etiological and Therapeutic Strategies for Neurodiseases: Mechanisms and Consequences of Febrile Seizures: Lessons From Animal Models
- ATTENUATION OF THE DEVELOPMENT OF HYPERTENSION IN SPONTANEOUSLY HYPERTENSIVE RATS BY CHRONIC ORAL ADMINISTRATION OF EICOSAPENTAENOIC ACID
- Vasopressin Induces Emesis in Suncus murinus
- Lysophosphatidylmethanol is a pan lysophosphatidic acid receptor agonist and is produced by autotaxin in blood
- High-Temperature, but Not High-Pressure, Conditions Alter Neuronal Activity
- Watching neuronal circuit dynamics through functional multineuron calcium imaging (fMCI)
- A Low-Cost Method for Brain Slice Cultures
- Elucidation With the Protease α-Chymotrypsin of the Inhibitory Modulating Action of Endogenous Neuropeptide Y Over Sympathetic Neurotransmission in Rat Vas Deferens
- INHIBITORY EFFECTS OF HISTAMINE ON CONTRACTION INDUCED BY TRANSMURAL STIMULATION IN RAT VAS DEFERENS
- Improvement of Fatigue and Acceleration of Recovery from Stress-Induced Deficient Sexual Behavior in Mice Following Oral Administration of Soft-Shelled Turtle Powder
- Anti-tumor Effects of Orally Administered Soft-Shelled Turtle Powder in Mice
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.
- Antiemetic Effects of Morphine on Motion- and Drug-Induced Emesis in Suncus murinus
- Involvement of a Peripheral Mechanism in the Emesis Induced by Cardiac Glycosides in Suncus murinus
- Involvement of α_2-Adrenergic Receptors in the Vagal Reflex-Induced Tracheal Constriction
- INHIBITION OF THE VAGAL REFLEX-INDUCED TRACHEAL CONSTRICTION BY PSYCHOTROPIC DRUGS
- Mechanisms of Increased Responses of the Aorta to α-Adrenoceptor Agonists in Streptozotocin-Induced Diabetic Rats
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. III. ACTIONS ON CARDIOVASCULAR SYSTEM AND ACUTE TOXICITY
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. II. AGONISTIC AND ANTAGONISTIC ACTIONS ON α-ADRENOCEPTORS IN VARIOUS SMOOTH MUSCLE PREPARATIONS
- PHARMACOLOGICAL STUDIES OF IMIDAZOLINE DERIVATIVES. I. A COMPARISON OF THE EFFECT ON PRE- AND POSTSYNAPTIC α-ADRENOCEPTORS IN THE RAT VAS DEFERENS
- Further Studies Concerning Possible Transmitters from NANC Nerves in the Circular Muscle of the Rat Stomach Fundus
- PLATELET ACTIVATING FACTOR : LACK OF DIRECT CARDIAC ACTION AND POSSIBLE TRANSMITTER RELEASE FROM CARDIAC SYMPATHETIC NERVE ENDINGS AT HIGH CONCENTRATIONS. ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES WITH GUINEA PIG VENTRICULAR MYOCARDIUM
- Effects of Calmodulin Antagonist (W-7) on Phorbol Ester (PMA)-induced Contractile Response in Isolated Rat Aorta
- Effect of phorbol 12, 13-dibutyrate on smooth muscle tone in rat stomach fundus
- Diabetes-related changes in contractile responses of stomach fundus to endothelin-1 in streptozotocin-induced diabetic rats
- D-Glutamic Acid-Induced Muscle Contraction in the Silkworm, Bombyx mori
- Ca^-Independent Phospholipase A_2 Inhibitor Impairs Spatial Memory of Mice
- POTENTIATION BY BOVINE SERUM ALBUMIN (BSA) OF ENDOTHELIUM-DEPENDENT VASODILATOR RESPONSE TO ACETYL GLYCERYL ETHER PHOSPHORYLCHOLINE (AGEPC)
- Prominent induction of cyclin B1 in G2/M renal cancer cells with butyrolactone 1
- Differences in cell kinetic changes among renal cancer cell lines treated with interferon-α
- The effect of papaverine on morphologic differentiation,proliferation and invasive potential of human prostatic cancer LNCaP cells
- CP2289,a New 5-HT_3 Receptor Ligand : Agonistic Activities on Gastroenteric Motility
- RENAL MICROSOMAL N-NITROSODIMETHYLAMINE DEMETHYLASE DETERMINED BY A SENSITIVE RADIOMETRIC METHOD
- STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite.
- Asynchronously Enhanced Spiking Activity of Ischemic Neuronal Networks
- Oseltamivir Enhances Hippocampal Network Synchronization
- Cryopreservation of Granule Cells From the Postnatal Rat Hippocampus
- 副腎疾患の診断と治療選択基準 : 犬の副腎皮質機能亢進症
- Hyperpolarization-Activated Current I_h in Nucleus of Solitary Tract Neurons : Regional Difference in Serotonergic Modulation
- Deterioration of Spatial Learning Performances in Lipopolysaccharide-Treated Mice
- Cortical Astrocytes Exposed to Tributyltin Undergo Morphological Changes In Vitro
- Cytotoxicity of tributyltin in rat hippocampal slice cultures
- Soluble Guanylyl Cyclase Inhibitor Prevents Sema3F-Induced Collapse of Axonal and Dendritic Growth Cones of Dentate Granule Cells(Molecular and Cell Biology)
- EFFECTS OF HYPOXIA AND REOXYGENATION ON TISSUE ATP LEVEL AND ELECTRICAL AND MECHANICAL FUNCTION OF ISOLATED GUINEA PIG VENTRICULAR MUSCLES.
- EFFECTS OF HYPOXIA AND METABOLIC INHIBITORS ON THE ELECTRICAL AND MECHANICAL ACTIVITIES OF ISOLATED GUINEA PIG PAPILLARY MUSCLES
- ELECTROPHYSIOLOGICAL EFFECTS OF A NEW ANTIARRHYTHMIC AGENT, LORCAINIDE, ON THE ISOLATED CARDIAC MUSCLE FIBER AS COMPARED WITH DISOPYRAMIDE
- Intracellular Ca^ Increase in Neuro-2A Cells and Rat Astrocytes Following Stimulation of Bradykinin B_2 Receptor
- Effects of L-Tryptophan on the Effects of Antitussives
- Effects of Double-enkephalin (Biphalin), an Enkephalin Analogue, on Respiration and the Cough Reflex in Rats
- Effect of Diabetes on the Morphine-Induced Inhibition of Gastrointestinal Tranist
- NEGATIVE CHRONOTROPIC EFFECT OF DIBUTYRYL CYCLIC AMP ON THE CULTURED CHICK EMBRYONIC HEART CELLS AND THE PROLONGATION OF THE ACTION POTENTIAL DURATION
- THE MECHANISM OF AGGRAVATION OF INDOMETHACIN-INDUCED GASTRIC ULCERS BY ADRENALECTOMY IN THE RAT
- Propranolol Blocks Cocaine-Induced Potentiation of the Contraction in the Smooth Muscle of the Rat Vas Deferens
- EFFECTS OF SMOOTH MUSCLE STIMULANTS ON I-ISOPRENALINE-β-ADRENOCEPTOR INTERACTION IN TAENIA FROM GUINEA PIG CAECUM
- EFFECTS OF VARIOUS DRUGS AND VAGOTOMY ON INDOMETHACIN-INDUCED GASTRIC ULCERS IN THE RAT
- INHIBITORY ALPHA-ADRENERGIC ACTION OF PHENYLEPHRINE IN GUINEA PIG TAENIA CAECUM
- EFFECTS OF COCAINE ON Ca-MOBILITY IN MICROSOMAL FRACTION FROM RAT VAS DEFERENS
- EFFECTS OF ACETYLCHOLINE AND HISTAMINE ON MECHANICAL ACTIVITY OF RABBIT TAENIA COLI, Ca-INCORPORATION AND Ca-RELEASE IN ITS MICROSOMAL FRACTION
- NONSPECIFIC RELAXATION OF INTESTINAL SMOOTH MUSCLE INDUCED BY ANTISPASMODICS AND MOVEMENT OF CALCIUM IONS
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON GLYCOGEN PHOSPHORYLASE ACTIVITY IN DEPOLARIZED TAENIA CAECUM OF GUINEA PIG
- EFFECTS OF NONSPECIFIC SMOOTH MUSCLE RELAXANTS ON TISSUE CONCENTRATIONS OF HIGH ENERGY PHOSPHATES AND MECHANICAL ACTIVITY OF NORMAL POLARIZED AND DEPOLARIZED INTESTINAL SMOOTH MUSCLES FROM GUINEA PIG
- Hyperactivity in novel environment with increased dopamine and impaired novelty preference in apoptosis signal-regulating kinase 1 (ASK1)-deficient mice
- Intracellular Calcium Oscillation in Cultured Rat Hippcampal Neurons: A Model for Glutamatergic Neurotransmission
- POSSIBLE ROLE OF ENDOTHELIUM IN THE VASODILATOR RESPONSE OF RAT THORACIC AORTA TO PLATELET ACTIVATING FACTOR (PAF)
- STUDIES ON THE HYPOTENSIVE EFFECTS OF PLATELET ACTIVATING FACTOR (PAF, 1-o-ALKYL-2-ACETYL-sn-GLYCERYL-3-PHOSPHORYLCHOLINE) IN RATS, GUINEA PIGS, RABBITS, AND DOGS
- ELECTROPHYSIOLOGICAL AND MECHANICAL STUDIES ON THE CARDIAC EFFECTS OF A HISTAMINE H_2 RECEPTOR ANTAGONIST, CIMETIDINE, IN THE ISOLATED GUINEA PIG MYOCARDIUM
- EVIDENCE FOR A DIRECT ACTION OF X-537A ON THE CARDIAC PLASMA MEMBRANE AS AN IONOPHORE
- Preservation of Endothelium-Dependent Vascular Relaxation in Cholesterol-Fed Mice by the Chronic Administration of Prazosin or Pravastatin
- INHIBITION BY PROPRANOLOL OF HIGH POTASSIUM-INDUCED CONTRACTIONS IN THE RAT VAS DEFERENS
- A COMPARATIVE STUDY OF CHANGES IN INNERVATION AND DEVELOPMENT OF SUPERSENSITIVITY IN THE RAT VAS DEFERENS AFTER VARIOUS PROCEDURES
- Novel Etiological and Therapeutic Strategies for Neurodiseases : Mechanisms and Consequences of Febrile Seizures : Lessons From Animal Models
- EFFECTS OF VARIOUS DRUGS AND EXTRINSIC DENERVATION ON THE NON-ADRENERGIC INHIBITORY NEURONS IN THE RAT STOMACH
- RENAL TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSHATE IN MICE.
- ACUTE TOXICITY OF ADENOSINE 3', 5'-CYCLIC MONOPHOSPHATE
- CARDIOTONIC EFFECT OF PHTHALAZINOL (EG-626) IN THE ISOLATED GUINEA PIG MYOCARDIUM : MECHANICAL AND ELECTROPHYSIOLOGICAL STUDY
- EFFECTS OF 15(S)-15-METHYL-PGE2 METHYL ESTER ON HEALING OF CHRONIC GASTRIC AND DUODENAL ULCERS IN RATS
- DESENSITIZATION OF GUINEA PIG TRACHEAL MUSCLE PREPARATION TO BETA-ADRENERGIC STIMULANTS BY A PRECEDING EXPOSURE TO A HIGH DOSE OF CATECHOLAMINES
- INFLUENCE OF SURGICAL SYMPATHECTOMY ON GASTRIC SECRETION AND ULCERATION IN RATS
- Basic Fibroblast Growth Factor and Brain-Derived Neurotrophic Factor Promote Survival and Neuronal Circuit Formation in Organotypic Hippocampal Culture
- Effects of coculture with the septum on the expression of long-term potentiation in organotypic hippocampal slice cultures
- Intact internal dynamics of the neocortex in acutely paralyzed mice
- Measurement of cellular 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT) reduction activity and lactate dehydrogenase release using MTT
- S2-4 MECHANISMS OF VOMITING(SYMPOSIUM 2: THE MECHANISMS INVOLVED IN EMESIS ASSOCIATED WITH VARIOUS DRUGS)(Proceedings of the 31st Annual Meeting)
- Cannabinoid Receptor Activation Disrupts the Internal Structure of Hippocampal Sharp Wave-Ripple Complexes
- Nitric Oxide but Not Carbon Monoxide Is Involved in Spatial Learning of Mice
- Postsynaptic Potentiation of Neurotransmission by Neurokinin A in Rat Vas Deferens.
- Analysis of New Imidazoline Derivative-Induced Increase in the Maximum Response to Norepinephrine in the Rat Vas Deferens
- Deficiency of .BETA.-adrenoceptor-mediated relaxation in Suncus trachea.
- Cisplatin-Induced Emesis in Suncus Murinus.
- Antiemetic Effects of Serotonergic 5-HT1A-Receptor Agonists in Suncus Murinus.
- Emesis induced by cancer chemotherapeutic agents in the Suncus murinus: A new experimental model.
- Involvement of Carbon Monoxide in Long-Term Potentiation in the Dentate Gyrus of Anesthetized Rats.
- Pharmacological Properties of Blood Pressure and Heart Rate Control in Suncus.
- Defect in an Intrahepatic Degradation of Apolipoprotein B in Suncus: An Animal Model of Hypobetalipoproteinemia.