A COMPARATIVE STUDY OF CHANGES IN INNERVATION AND DEVELOPMENT OF SUPERSENSITIVITY IN THE RAT VAS DEFERENS AFTER VARIOUS PROCEDURES
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概要
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The relationship between morphological and functional changes in adrenergic nerves and the development of supersensitivity in the rat vas deferens was comparatively investigated after surgical denervation, chemical sympathectomy by 6-hydroxydopamine, daily treatment of animals with reserpine, or local application of colchicine to the hypogastric plexus. The order of ability to produce supersensitivity, as judged by the extent of the increase in the pD<SUB>2</SUB> value of norepinephrine and the maximum response to norepinephrine, was as follows: denervation=colchicine> 6-hydroxydopamine>reserpine. These procedures produced alterations in morphological characteristics of the nerve ending with severeness of degeneration in the following order: denervation>6-hydroxydopamine>colchicine>reserpine. Twitch contractions induced by transmural nerve stimulation were slightly reduced after colchicine or 6-hydroxydopamine treatment, markedly reduced by reserpine, and abolished by denervation. Therefore, the development of supersensitivity in the rat vas deferens is not necessarily in proportion to the morphological or functional changes in adrenergic nerves. The results suggest that some neurofactor, e.g. trophic factor, is involved in the control of the drug sensitivity of smooth muscle in addition to the neurotransmitter itself.
- 社団法人 日本薬理学会の論文
著者
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SAITO AKIRA
Department of Pediatrics, Hirosaki University School of Medicine
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Goto Katsutoshi
Department Of Pharmacology Institute Of Basic Medical Sciences The University Of Tsukuba
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Kasuya Y
Department Of Pharmacology Hoshi University School Of Pharmaceutical Sciences
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Saito Akira
Department Of Pathology Juntendo University Urayasu Hospital
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Goto Katsutoshi
Department Of Ophthalmology Kawasaki Medical School
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Saito Akira
Department of Biological Chemistry, Yamaguchi University
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Saito Akira
Department of Applied and Bioapplied Chemistry, Graduate School of Engineering, Osaka City University
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