STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. I. : Measurement of the amount of nitrosamine formed in rat and guinea pig stomachs.

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概要

• 論文の詳細を見る

• The amounts of nitrosamine formed by the interaction of several drugs and nitrite in rat and guinea pig stomachs were estimated. The nitrosamine formation from aminopyrine and nitrite was much more in guinea pig stomachs than in rat stomachs. It seemed that this result was due to the difference in gastric contents of these animals. As the nitrosamine formation was also indicated in the interaction of a clinically prescribed dose of aminopyrine and very low doses of nitrite in rat and guinea pig stomachs, there is a possibility that the nitrosation of aminopyrine takes place in human stomachs, too. Minocycline also interacted with nitrite and formed N-nitrosodimethylamine. However, the amount of nitrosamine formed was less in minocycline than in aminopyrine. Oxytetracycline was not found to form nitrosamine in the stomachs of these animals. The effects of several compounds on the nitrosamine formation by the interaction of aminopyrine and nitrite were also investigated. Ascorbic acid, sodium erythorbate, propyl gallate and butylated hydroxyanisole reduced the nitrosamine formation but the effect of alphatocopherol, sorbic acid and butylated hydroxytoluene was not observed in the stomach.

• 日本トキシコロジー学会の論文
• 1981-11-25

著者

• Ohno Yasuo

  National Institute of Health Sciences

• Ohno Yasuo

  Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences

• Kawanishi Toru

  Div. Of Drugs National Inst. Of Health Sci. Jpn

• Kawanishi T

  大妻女子大学 食物学科

• Kawanishi T

  Division Of Drugs National Institute Of Health Science

• Kawanishi Toru

  National Institute Of Health Sciences

• TAKAHASHI Atsushi

  National Institute of Hygienic Sciences

• OMORI Yoshihito

  National Institute of Hygienic Sciences

• Takahashi Atsushi

  Division Of Pharmacology National Institute Of Hygienic Sciences

• KASUYA YUTAKA

  Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo

• KOBAYASI TADASHI

  Kobe Pharmaceutical University

• Kasuya Y

  Hoshi Univ. Tokyo Jpn

• Kawanishi Toru

  Division Of Drugs National Institute Of Health Science

• Kawanishi Toru

  国立医薬品食品衛生研究所

• Tanimura Akio

  National Institute Of Hygienic Sciences Biological Safety Research Center Division Of Food Additives

• ISHIWATA Hajime

  National Institute of hygienic sciences, Biological Safety Research Center Division of Food Additive

• TAKANAKA Akira

  The Organization for Pharmaceutical Safety and Research

• Kasuya Yutaka

  Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo

• Takanaka Akira

  Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences

• Takanaka A

  National Inst. Hygienic Sciences Tokyo Jpn

• Takahashi Atsushi

  National Institute Of Health Sciences

• Kawanishi Toru

  Division Of Pharmacology National Institute Of Hygienic Sciences

• Ishiwata Hajime

  National Institute Of Hygienic Sciences Biological Safety Research Center Division Of Food Additives

• Ohno Yasuo

  National Inst. Of Health Sci. Tokyo Jpn

• Takahashi A

  Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences

• Takahashi Atsushi

  National Institute Of Advanced Industrial Science And Technology

• TANIMURA Akio

  National Institute of Hygenic Science

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