EFFECTS OF VARIOUS INDUCERS ON THE ACTIVITIES OF CYTOCHROME P-450-MIXED FUNCTION OXIDASES AND AFLATOXIN B_1 ACTIVATION IN MICROSOMES OF HAMSTER LIVERS
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概要
- 論文の詳細を見る
The effects of various inducers on the activities of drug-metabolizing enzymes including aflatoxin B_1 activation were studied in Syrian golden hamsters. Activity for aflatoxin B_1 was determined by aflatoxin B_1-DNA adducts formation. The treatments of hamsters with 3-methylcholanthrene, α-naphthoflavone and benzo(a)pyrene elevated markedly the activity for aflatoxin B_1 by 2460, 1380 and 450%, respectively. Phenobarbital induced slightly and isosafrole and ethanol did not induce the activity for aflatoxin B_1. Pregnenolone-16α-carbonitrile decreased aflatoxin B_1 activation to 51% of that of the non-treated animals. These results were in good accordance with the induction rate of a form of cytochrome P-450(P-450_<AFB>) which has potent activity to aflatoxin B_1. Characteristics in the induction of mixed function oxidases of hamsters by these inducers, especially in respect to benzo(a)pyrene metabolizing enzyme, seemed to differ from those of rats. These results suggest that the activity for aflatoxin B_1 in hamster is inducible by 3-methylcholanthrene-type inducers and that hamster is a suitable animals model to study the mechanism of aflatoxin B_1-hepatocarcinogenesis.
- 日本トキシコロジー学会の論文
- 1988-11-25
著者
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OHNO Yasuo
Division of Pharmacology, National Institute of Health Science
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Ohe Yuichiro
国立医薬品食品衛生研究所
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Ohe Yuichiro
Department Of Medical Oncology National Cancer Center Hospital
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SUNOUCHI Momoko
Division of Pharmacology, National Institute of Health Sciences
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SUNOUCHI Momoko
Div. Pharmacol., Natl. Inst. Health Sci.
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TAKANAKA Akira
Division of Pharmacology, BSRC, National Institute of Hygienic Sciences
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Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
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Takahashi Atsushi
Division Of Pharmacology National Institute Of Hygienic Sciences
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TAKANAKA Akira
The Organization for Pharmaceutical Safety and Research
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FUKUHARA MORIO
Department of Pharmaceutical Sciences, National Institute of Public Health
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Fukuhara M
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Fukuhara Morio
Department Of Pharmaceutical Sciences
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Takanaka Akira
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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Takanaka A
National Inst. Hygienic Sciences Tokyo Jpn
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Sunouchi Momoko
Div. Pharmacol. Natl. Inst. Health Sci.
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Sunouchi Momoko
Division Of Pharmacology National Institute Of Hygienic Sciences
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Sunouchi Momoko
Div. Of Pharmacology National Institute Of Hygienic Sciences
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Sunouchi Momoko
Division Of Pharmacol. Mutagen. Nihs
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Fukuhara Morio
Department Of Pharmaceutical Sciences National Institute Of Public Health
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Ohno Yasuo
Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital
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Takahashi A
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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