EFFECTS ON FETAL GROWTH OF REPEATED BLOOD COLLECTION FOR TOXICOKINETICS FROM PREGNANT RATS
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概要
- 論文の詳細を見る
Repeated blood collection from pregnant rats was examined for effects on fetuses. Blood was collected four times from the same pregnant rat (0.5 ml each time and 2 ml in total). In Experiment 1, blood was first collected on day 9 of gestation and then repeatedly at 1, 4 and 18 hr intervals. In Experiment 2, blood was collected once on day 6 of gestation and then repeatedly on days 9, 12 and 15. Decreases in body weight and food consumption of the pregnant animals were noted in both experiments and considered due to restraint and needle puncture. In neither experiment could any effects be found on day 20 of gestation with regard to viability, fetal weight, placental weight or gross malformation. The results indicated that this regimen of blood collection could be used in developmental toxicity assessment studies.
- 日本トキシコロジー学会の論文
- 1997-12-15
著者
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OHNO Yasuo
Division of Pharmacology, National Institute of Health Science
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Ohe Yuichiro
国立医薬品食品衛生研究所
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Ohe Yuichiro
Department Of Medical Oncology National Cancer Center Hospital
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Takagi H
Univ. Tokyo Tokyo Jpn
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Ohno Y
Division Of Pharmacology National Institute Of Health Sciences
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Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
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Usami Makoto
Division of Pharmacology, National Institute of Health Sciences
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Hatano T
The Institute For Solid State Physics The University Of Tokyo
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TAKAHASHI Hiroki
Laboratory of Biomolecular Dynamics, Department of Physics, Kitasato University School of Science
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SASAKI Masanori
Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry,
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Hashimoto T
Nec Corp. Kanagawa Jpn
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KOBAYASHI Youshiro
Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry
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Nakajima Mikio
Laboratory For Toxicological Research Institute For Life Science Research Asahi Chemical Industry Co
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Nakajima Mikio
Laboratory For Safety Assessment & Adme Pharmaceuticals Research Center Asahi Kasei Pharma Corpo
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Takahashi H
Univ. Tokyo Chiba
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Kobayashi Y
Faculty Of Pharmaceutical Sciences Teikyo University Sagamiko
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Kobayashi Y
Department Of Clinical Pharmacy School Of Pharmaceutical Sciences Showa University
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Omori Yoshihito
Division Of Pharmacology National Institute Of Hygienic Sciences
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Sasaki M
Banyu Pharmaceutical Co. Ltd. Saitama Jpn
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Ohno Yasuo
National Inst. Of Health Sci. Tokyo Jpn
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Ohno Yasuo
Division Of Internal Medicine And Thoracic Oncology National Cancer Center Hospital
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Usami Makoto
Division Of Pathology National Institute Of Health Sciences
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Takahashi Hiroki
Laboratory Of Biomolecular Dynamics Department Of Physics Kitasato University School Of Science
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Takahashi Hiroki
Saclay:Russian Research Center "Kurchatov Institute"
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Sasaki Masanori
Laboratory for Toxicological Research, Institute for Life Science Research, Asahi Chemical Industry Co., Ltd.
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Usami Makoto
Division of Nutrition and Metabolism, Department of Biophysics, Kobe University Graduate School of Health Sciences
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Takahashi Haruyuki
Saclay:Russian Research Center "Kurchatov Institute"
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