STUDIES ON NITROSAMINE FORMATION BY THE INTERACTION BETWEEN DRUGS AND NITRITE. II. : Hepatotoxicity by the simultaneous administration of several drugs and nitrite.
スポンサーリンク
概要
- 論文の詳細を見る
The alterations of biochemical parameters, namely, glutamic oxaloacetic transaminase and glutamic pyruvic transaminase in serum, hepatic microsomal drug oxidation systems, glucose-6-phosphate dehydrogenase and lysozomal enzymes in hepatic soluble fraction were investigated for the purpose of semiquantitatively estimating the hepatotoxicity caused by the interaction of several drugs and sodium nitrite in rats. The simultaneous administration of aminopyrine and sodium nitrite induced the alterations of these parameters. However, these alterations were not induced by the administration of antipyrine and sodium nitrite. Therefore the alterations were thought to be mainly due to N-nitrosodimethylamine formed. The administration of 0.4 mmole/kg of aminopyrine and 1.0 mmole/kg of sodium nitrite was thought to induce the alterations to almost the same extent as induced by 0.15 mmole/kg of N-nitrosodimethylamine. The simultaneous administrations of sodium nitrite and several other drugs with tertiary amino groups, namely, oxytetracycline, diphenhydramine, oleandomycin, erythromycin and minocycline induced small alterations of these parameters. However, these alterations were not thought to relate to the hepatic injury induced by N-nitrosodimethylamine. Therefore the amount of N-nitrosodimethylamine formed from these drugs in rats was thought to be rather small. We also investigated the effect of several antioxidants on the alterations of biochemical parameters induced by aminopyrine and sodium nitrite. Ascorbic acid, sodium erythorbate and propyl gallate inhibited these alterations. On the other hand, sorbic acid did not.
- 日本トキシコロジー学会の論文
- 1981-11-25
著者
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Ohno Yasuo
National Institute of Health Sciences
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Ohno Yasuo
Div. Of Pharmacology Biological Safty Research Center National Institute Of Hygienic Sciences
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Kawanishi Toru
Div. Of Drugs National Inst. Of Health Sci. Jpn
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Kawanishi T
大妻女子大学 食物学科
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
National Institute Of Health Sciences
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TAKAHASHI Atsushi
National Institute of Hygienic Sciences
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OMORI Yoshihito
National Institute of Hygienic Sciences
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Takahashi Atsushi
Division Of Pharmacology National Institute Of Hygienic Sciences
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Kasuya Y
Hoshi Univ. Tokyo Jpn
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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TAKANAKA Akira
The Organization for Pharmaceutical Safety and Research
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Onoda Kin-ichi
National Institute Of Hygienic Sciences Biological Safety Research Center Division Of Pharmacology
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Takanaka Akira
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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Takanaka A
National Inst. Hygienic Sciences Tokyo Jpn
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Takahashi Atsushi
National Institute Of Health Sciences
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Sunouchi Momoko
Div. Pharmacol. Natl. Inst. Health Sci.
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Kawanishi Toru
Division Of Pharmacology National Institute Of Hygienic Sciences
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SUNOUCHI Momoko
National Institute of hygienic sciences, Biological Safety Research Center Division of Pharmacology
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Sunouchi Momoko
Division Of Pharmacology National Institute Of Hygienic Sciences
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Ohno Yasuo
National Inst. Of Health Sci. Tokyo Jpn
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Takahashi A
Division Of Pharmacology Bsrc National Institute Of Hygienic Sciences
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Takahashi Atsushi
National Institute Of Advanced Industrial Science And Technology
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Sunouchi Momoko
National Institute Of Hygienic Sciences Biological Safety Research Center Division Of Pharmacology
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