INHIBITORY EFFECTS OF HISTAMINE ON CONTRACTION INDUCED BY TRANSMURAL STIMULATION IN RAT VAS DEFERENS
スポンサーリンク
概要
- 論文の詳細を見る
The effect of histamine on the contractions induced by neuromuscular transmission in the isolated rat vas deferens was investigated. Histamine, 10^-6-10-4M, showed a dose-dependent and reversible inhibition of the induced contractions. When the frequency of stimulation was altered(2.5-20Hz), the inhibitory effect tended to be marked at the lower frequencied. Contractions caused by norepinephrine, 10^-5M, were unaffected by histamine, indicating that the inhibitory effect of histamine was not due to a reduced sensitivity of the effector cells to the transmitter. Cimetidine, 7×10^-5M, diminished the response to histamine but chlorpheniramine, 10^-6M, did not. The results suggest that the inhibitory effect of histamine is mediated via H_2-receptors probably located at the adrenergic nerve terminal.
- 公益社団法人日本薬学会の論文
著者
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KATO Hitoshi
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Teikyo University
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Eun-hee Park
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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KASUYA YUTAKA
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Kato Hitoshi
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Teikyo University
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Kato Hitoshi
Department Of Pediatrics Graduate School Of Medicine University Of Tokyo
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KATO Hitoshi
Department of Chemical Pharmacology, Faculty of Pharmaceutical Sciences, University of Tokyo
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