ELECTROPHYSIOLOGICAL STUDY ON THE SO-CALLED SENSITIZING EFFECT OF HALOTHANE TO CATECHOLAMINES IN THE DOG CARDIAC MUSCLE
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概要
- 論文の詳細を見る
The electrophysiological basis of pharmacological actions of halothane on canine cardiac fibers was examined to elucidate the mechanism of the induction of the arrhythmia by the combination of anesthetic and epinephrine. The pacemaker activity of the right bundle branch (RBB) was compared with that of the sinus node under the influence of halothane and epinephrine. In the spontaneously active fiber of RBB, halothane (1.3% v/v) caused remarkable increase in the slope of pacemaker potential and in the rate of firing in most preparations. In contrast, halothane produced a profound depression in pacemaker activity of the sinus node in half number of preparations, but the remaining preparations were not affected significantly. The positive chronotropic action of epinephrine was augmented by halothane in RBB preparations, while the enhancement was not observed in atrial preparations. These effects might result in an enhanced liability to arrhythmia.
- 日本トキシコロジー学会の論文
- 1977-01-15
著者
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Kasuya Yutaka
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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HAYASHI Shigehiro
Department of Pharmacology, Shiga University of Medical Sciences
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Hayashi Shigehiro
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(pr
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Kasuya Yutaka
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo:(pr
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Watanabe Minoru
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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Watanabe Minoru
Department Of Chemical Pharmacolgy Faculty Of Pharmaceutical Sciences Nagoya City University
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Shigenobu Koki
Department Of Toxicology And Pharmacology Faculty Of Pharmaceutical Sciences University Of Tokyo
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HAYASHI Shigehiro
Department of Pharmacology, Faculty of Medicine Kyoto University
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