Involvement of the Na^+/Ca^<2+> Exchanger in Ouabain-Induced Inotropy and Arrhythmogenesis in Guinea-Pig Myocardium as Revealed by SEA0400
スポンサーリンク
概要
- 論文の詳細を見る
Involvement of the Na+/Ca2+ exchanger in ouabain-induced inotropy and arrhythmogenesis was examined with a specific inhibitor, SEA0400. In right ventricular papillary muscle isolated from guinea-pig ventricle, 1 μM SEA0400, which specifically inhibits the Na+/Ca2+ exchanger by 80%, reduced the ouabain (1 μM)-induced positive inotropy by 40%, but had no effect on the inotropy induced by 100 μM isobutyl methylxantine. SEA0400 significantly inhibited the contracture induced by low Na+ solution. In HEK293 cells expressing the Na+/Ca2+ exchanger, 1 μM ouabain induced an increase in intracellular Ca2+, which was inhibited by SEA0400. The arrhythmic contractions induced by 3 μM ouabain were significantly reduced by SEA0400. These results provide pharmacological evidence that the Na+/Ca2+ exchanger is involved in ouabain-induced inotropy and arrhythmogenesis.
- 社団法人 日本薬理学会の論文
- 2007-02-20
著者
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Shimada Hideaki
Department of Tissue and Organ Development, Regeneration and Advanced Medical Science, Gifu Universi
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Iida Tanaka
Department Of Food Science Otsuma Women's University
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Shimada Hideaki
千葉大学 医学研究院先端応用外科学
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Shimada H
Department Of Frontier Surgery Graduate School Of Medicine Chiba University
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KAWANISHI Toru
Division of Biological Chemistry and Biologicals, National Institute of Health Sciences
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Kawanishi T
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
Division Of Biological Chemistry And Biologicals National Institute Of Health Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Shiina Hiroyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shimada Hideaki
Department Of Gastroenterological Surgery Chiba Cancer Center
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Namekata Iyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Shimada H
Kumamoto Univ. Kumamoto
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Shimada Hideaki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Science
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KOBAYASI TADASHI
Kobe Pharmaceutical University
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Kawanishi Toru
Division Of Drugs National Institute Of Health Science
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Kawanishi Toru
国立医薬品食品衛生研究所
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Shimada Hideaki
Department Of Frontier Surgery Chiba University Graduate School Of Medicine
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Shimada Hideaki
Department Of Academic Surgery Graduate School Of Medicine Chiba University
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Iida Tanaka
Department Of Food Science Faculty Of Home Economics Otsuma Woman's University
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TANAKA Hiraru
Department of Pharmacology, Toho University Faculty of Pharmaceutical Science
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Sakurai Haruna
Department Of Pharmacology School Of Pharmaceutical Sciences Showa University
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Sashiyama Hiroshi
千葉大学 医学研究院先端応用外科学
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古林 隆司
宇部興産株式会社研究開発本部宇部研究所医薬研究部
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Shimada Hideaki
Department Of Academic Surgery (m9) Graduate School Of Medicine Chiba University
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Namekata Iyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Namekata Iyuki
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Toho University
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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