Lack of Action Potential-Prolonging Effect of Terfenadine on Rabbit Myocardial Tissue Preparations(Pharmacology)
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概要
- 論文の詳細を見る
The effects of terfenadine, an antiallergic drug also known for its QT-prolonging and arrhythmogenic activities, on the action potential of isolated myocardial tissue preparations from rabbits were examined with microelectrode techniques. In the Purkinje fibers and atrium, terfenadine concentration dependency decreased the maximum rate of rise (+V^^・_<max>) without affecting other action potential parameters. In the ventricle, terfenadine had little effect on action potential configuration. In the sinoatrial node, terfenadine 20μM prolonged cycle length mainly through inhibition of +V^^・_<max>. Terfenadine 1 μM completely inhibited the human ether a go-go-related gene (HERG) channel current expressed in HEK293 cells in the same experimental solution as in microelectrode experiments. The lack of terfenadine effect on the action potential duration suggests that there are drugs for which the HERG channel inhibitory action underlying in vivo QT prolongation cannot be evaluated based on their action potential-prolonging activity in isolated myocardial tissue preparations.
- 社団法人日本薬学会の論文
- 2004-01-01
著者
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Ito M
Meijo Univ. Nagoya Jpn
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Saito Mariko
Department of Internal Medicine, Nagasaki University
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Iida-tanaka Naoko
Department Of Food Science Otsuma Women's University
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Ito M
Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito Michiho
北里大学 薬学部
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MASUMIYA Haruko
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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TANAKA Hikaru
Department of Pharmacology, Toho University School of
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SHIGENOBU Koki
Department of Pharmacology, Toho University School of
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Saito Mariko
Department Of Chemistry Faculty Of Science Ochanomizu University
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Saito Mariko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Toho Univ. Fac. Of Pharmaceutical Sciences Jpn
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Tanaka H
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu K
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Shigenobu Koki
Department Of Chemical Pharmacology Faculty Of Pharmaceutical Sciences The University Of Tokyo
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Matsuda Tomoyuki
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Toho University
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ITO Mie
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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NOGUCHI Kazuo
Department of Pharmacology, Toho University School of Pharmaceutical Sciences
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Tanaka Hikaru
Dep. Of Pharmacology Fac. Of Pharmaceutical Sciences Toho Univ.
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Tanaka Hikaru
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Shigenobu Koki
Toho University School Of Pharmaceutical Sciences
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Masumiya Haruko
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Ito Mie
Department Of Applied Biological Chemistry Graduate School Of Agricultural And Life Sciences Univers
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Noguchi Kazuo
Department Of Cellular And System Physiology Graduate School Of Medical Sciences Kyushu University
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Noguchi Kazuo
Department Of Pharmacology Toho University School Of Pharmaceutical Sciences
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Tanaka Hikaru
Department Of Internal Medicine Sasebo Senjyu Hospital
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Matsuda Tomoyuki
Department Of Pharmacology Toho University Faculty Of Pharmaceutical Sciences
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Matsuda Tomoyuki
Department Of Anesthesiology And Anatomy And Neurobiology Kyoto Prefectural University Of Medicine
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Tanaka Hikaru
Department Of Internal Medicine Hirosaki Municipal Hospital
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Tanaka Hikaru
Department of Endocrinology and Metabolism, Hirosaki University
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Iida-Tanaka Naoko
Department of Biochemistry, Teikyo University School of Medicine
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