New Sesquiterpene Hydroperoxides with Trypanocidal Activity from Pogostemon cablin

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概要

• 論文の詳細を見る

• Trypanocidal constituents of Pogostemon cablin were investigated. Activity guided isolation of the acetone extract resulted in isolation of three new sesquiterpene hydroperoxides 1-3, together with a known sesquiterpene, patchouli alcohol (4). In vitro minimum lethal concentrations of the hydroperoxides 1-3 against epimastigotes of Trypanosoma cruzi were 0.84 μM (1), 1.7 μM (2) and 1.7 μM (3). The activity of the corresponding alcohols and patchouli alcohol was very weak (MLC>200 μM).

• 公益社団法人日本薬学会の論文
• 2004-12-01

著者

• Ito M

  Meijo Univ. Nagoya Jpn

• Matsunaga Keiji

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito M

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito M

  Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito Michiho

  北里大学 薬学部

• Qui T

  Research Center For Applied Chemistry Vietnam National University

• KIUCHI Fumiyuki

  Tsukuba Medicinal Plant Research Station, National Institute of Health Sciences

• MATSUO Kenji

  Graduate School of Pharmaceutical Sciences, Kyoto University

• ITO Michiho

  Graduate School of Pharmaceutical Sciences, Kyoto University

• QUI Tran

  Research Center for Applied Chemistry, Vietnam National University

• HONDA Gisho

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Ito Michiho

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi F

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi Fumiyuki

  国立医薬品衛生研究所

• Kikuchi F

  Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu

• Kikuchi F

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kiuchi Fumiyuki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi Fumiyuki

  Tsukuba Medicinal Plant Research Station National Institute Of Health Sciences

• Matsunaga Kazuhisa

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Matsunaga K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Gisho

  Department Of Pharmacognosy Graduate School Of Pharmaceutical Science Kyoto University

• Honda Gisho

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Honda Gisho

  Faculty Of Pharmaceutical Sciences Himeji Dokkyo University

• Matsuo K

  Kddi R&d Laboratories Inc.

• 木内 文之

  慶應義塾大学薬学部

• Kiuchi Fumiyuki

  Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu

• Qui Tran

  Research Center For Applied Chemistry Vietnam National University

• Kiuchi Fumiyuki

  Tsukuba Div. Res. Center For Medicinal Plant Resources National Inst. Of Biomedical Innovation

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