Enhancement of the Nerve Growth Factor-Mediated Neurite Outgrowth from PC12D Cells by Chinese and Paraguayan Medicinal Plants
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概要
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It is very important to search for natural compounds possessing nerve growth factor (NGF)-potentiating activity. Extracts of 7 Chinese and 10 Paraguayan medicinal plants were examined for their effects on the NGF-mediated neurite outgrowth from PC12D cells to evaluate their NGF-potentiating activities. In the methanol extracts, Gymmopteris rufa (LINN.) BERNH, Ruta graveolens LINN. and Picrorhiza scrophulariiflora PENNELL markedly increased the proportion of neurite-bearing cells. In the case of ethyl acetate fractions, Equisetum giganteum LINN. produced the most powerful enhancement of the proportion of the neurite-bearing cells, and the activities were in the following decreasing order : Equisetum giganteum LINN., Gymmopteris rufa (LINN.) BERNH, Ruta graveolens LINN., and Picrorhiza scrophulariiflora PENNELL. In the water fractions, Imperata cylindrica, Ginseng Radix, Gymmopteris rufa (LINN.) BERNH, Gochnatia polymorpha (LESS) CAB and Picrorhiza scrophulariiflora PENNELL caused a weak enhancement of the proportion of PC12D cells with neurites. Of all extracts and fractions, the methanol extract of Picrorhiza scrophulariiflora PENNELL induced the longest neurites in PC12D cells. In the ethyl acetate and water fractions of Nardostachys chinensis, long neurites were observed although only a small proportion of PC12D cells had neurites. On the other hand, in the ethyl acetate fraction of Equisetum gigantheum LINN., while the length of the neurites was short, the proportion of neurite-bearing cells was largest among all the extracts and fractions.
- 公益社団法人日本薬学会の論文
- 1999-07-15
著者
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Matsunaga Keiji
Graduate School Of Pharmaceutical Sciences Kyoto University
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OHIZUMI Yasushi
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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LI Ping
Department of Cell Biology Institute of Nephrology, Niigata University School of Medicine
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Li Ping
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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OHIZUMI Yasushi
Graduate School of Pharmaceutical Sciences, Tohoku University
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MATSUNAGA Kimihiro
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku U
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Yasushi Ohizumi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Matsunaga Kazuhisa
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga K
Faculty Of Pharmaceutical Sciences Fukuoka University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences
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Li Ping
Department Of Cardiology Nagoya University Gradute School Of Medicine
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Li P
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Matsunaga Kimihiro
Department Of Pharmaceutical Molecular Biology Faculty Of Pharmaceutical Sciences Tohoku University
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Mihashi Kunihide
Faculty Of Pharmaceutical Sciences Fukuoka University
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Ohizumi Yasushi
Department Of Anti-dementia Functional Food Development Graduate School Of Engineering Tohoku Univer
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Ohizumi Yasushi
Department Of Pharmaceutical Molecular Biology Graduate School Of Pharmaceutical Sciences Tohoku Uni
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Matsunaga Kimihiro
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
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