Trypanocidal Flavonoids from Sophora flavescens

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概要

• 論文の詳細を見る

• The acetone extract of Sophora flavescens Aiton (Leguminosae) exhibited lethal activity against Trypanosoma cruzi. Column chromatographic separation of the extract guided by trypanocidal activity afforded a new prenylated flavanone (4), together with nine known flavonoids: sophoraflavanone G (1), (-)-kurarinone (2), kushenol L (3), 2'-methoxykurarinone (5), 7,4'-dihydroxy-5-methoxy-8-(γ,γ-dimethylallyl)-flavanone (6), leachianone A (7), 8-prenylnaringenin (8), noranhydroicaritin (9) and alopecurone G (10). The structure of the new flavanone 4 was determined on the basis of spectroscopic analyses. The minimum lethal concentrations of these compounds against epimastigotes of T. cruzi were 3.7 μM(1), 14 μM(2), 7.1 μM(3), 7.2 μm(4), 6.9 μM(5), 71 μM (6), 5.5 μM (7), 18 μM (8), 4.4 μM (9) and 3.6 μM (10).

• 日本生薬学会の論文
• 2003-12-20

著者

• Ito M

  Meijo Univ. Nagoya Jpn

• Matsunaga Keiji

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito M

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito M

  Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University

• Ito Michiho

  北里大学 薬学部

• Qui T

  Research Center For Applied Chemistry Vietnam National University

• MATSUO Kenji

  Graduate School of Pharmaceutical Sciences, Kyoto University

• Ito Michiho

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi F

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi Fumiyuki

  国立医薬品衛生研究所

• Kikuchi F

  Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu

• Kikuchi F

  Faculty Of Pharmaceutical Sciences Kanazawa University

• Kiuchi Fumiyuki

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Matsunaga Kazuhisa

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Matsunaga K

  Faculty Of Pharmaceutical Sciences Fukuoka University

• Honda Gisho

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Honda Gisho

  Faculty Of Pharmaceutical Sciences Himeji Dokkyo University

• Honda G

  Graduate School Of Pharmaceutical Sciences Kyoto University

• Kiuchi Fumiyuki

  Faculty Of Pharmaceutical Sciences Kanazawa University:(present Address)graduate School Of Pharmaceu

• Qui Tran

  Research Center For Applied Chemistry Vietnam National University

• Mihashi Kunihide

  Faculty Of Pharmaceutical Sciences Fukuoka University

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