Molecular Recognition of Deoxycholic Acids by Pyrene-Appended γ-Cyclodextrin Connected with a Rigid Azacrown Spacer
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概要
- 論文の詳細を見る
A γ-cyclodextrin (γ-CyD) derivative (1) having a pyrene moiety, connected through a 4,13-diaza-18-crown-6 ether moiety to γ-CyD, was synthesized and evaluated for guest binding and sensing properties. In aqueous solution, 1 existed as an association dimer in which the secondary hydroxyl sides faced each other to accommodate two pyrene moieties. Photo-induced electron transfer (PET) between the amino group and the excited pyrene moiety regulated the monomer fluorescence intensity of 1. The monomer-dimer equilibrium and the PET indicated that 1 may be used as a host capable of detecting guest complexation by changes in fluorescence intensity from the pyrene moiety. Deoxycholic acids were found to be good guests for detection by 1,and deoxycholic acid itself induced different fluorescence changes compared to the other deoxycholic acids. This indicated that 1 could recognize the position of the hydroxy groups on the steroidal framework. The azacrown part may participate in the guest selectivity for the deoxycholic acids by regulating the distance between the amino group and the pyrene moiety, modifying PET efficiency.
- 公益社団法人日本薬学会の論文
- 1999-02-15
著者
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Ito M
Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito Michiho
北里大学 薬学部
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Anzai Jun-ichi
Faculty Of Pharmaceutical Sciences Tohoku University
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Suzuki Iwao
Faculty Of Pharmaceutical Sciences Tohoku University
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Osa T
Faculty Of Pharmaceutical Sciences Tohoku University
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ITO Maki
Faculty of Pharmaceutical Sciences, Tohoku University
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OSA Tetsuo
Faculty of Pharmaceutical Sciences, Tohoku University
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