New Model of Progressive Non-Insulin-Dependent Diabetes Mellitus In Mice Induced by Streptozotocin
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概要
- 論文の詳細を見る
This study was designed to clarify the relationship between streptozotocin (STZ) dosage (100,150 and 200 mg/kg i.p.) and the resulting diabetogenic response in mice (8-week-old male ICR). In this experiment, we found that a single i.p. injeciton of 100 mg/kg STZ is able to induce progressive diabetes mellitus, in which non-fasting serum glucose levels begin to rise from 3 weeks and continue to rise throughout the experimental period until 9 weeks. The non-fasting serum insulin levels of 100 mg/kg STZ-treated mice were normal during the experimental period. In addition, the population of insulin-immunoreactive cells (beta cells) in the islets of pancreata was slightly less than in normal mice at 9 weeks. In 200 mg/kg STZ-treated mice, on the other hand, the insulin levels were below measurable values and insulin-immunoreactive cells were not observed. It is concluded from these results that the progressive diabetic mouse model induced by a single i.p. injection fo 100 mg/kg STZ, unlike 200 mg/kg STZ-induced diabetes which is insulin-dependent, is non-insulin-dependent.
- 公益社団法人日本薬学会の論文
- 1999-09-15
著者
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ITO Mikio
Department of Materials Science and Processing, Graduate School of Engineering, Osaka University
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Ito Mikio
三和化学研究所総合研究所
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Ito M
Meijo Univ. Nagoya Jpn
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Ito M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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KONDO Yoichi
Department of Neuroscience, Institute of Molecular and Cellular Medicine, Okayama University Medical
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ITO Mikio
Laboratory of Analytical Pharmacology, Faculty of Pharmacy, Meijo University
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Kondo Yasunori
Nutrition Research Institute Otsuka Pharmaceutical Factory Inc.
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NAKATANI Akiko
Department of Pharmacology, Faculty of Phamacy, Meijo University 150 Yagotoyama
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NARUSE Atsuhiko
Department of Pharmacology, Faculty of Phamacy, Meijo University 150 Yagotoyama
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Nakatani Akiko
Laboratory Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
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Kondo Yoichi
Department Of Hygiene The National Defense Medical College
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Ito Mikio
Department Of Materials Science And Processing Graduate School Of Engineering Osaka University
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Naruse Atsuhiko
Department Of Pharmacology Faculty Of Phamacy Meijo University 150 Yagotoyama
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Ito Mikio
Department Of Analytical Pharmacology Faculty Of Pharmacy Meijo University
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Nakatani Akiko
Department of Applied Microbial Technology, Kumamoto Institute of Technology
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