Phenylethanoid Glycosides Targeting Mammalian DNA Polymerases
スポンサーリンク
概要
- 論文の詳細を見る
In our continuing search to discover bioactive compounds from medicinal plants, a methanolic extract of Verbascum songaricum collected in Kazakhstan was investigated. Activity-guided fractionation of the extract prepared from the plant, using a sensitive assay to monitor DNA polymerase reactions, resulted in the isolation of two known phenylethanoid glycosides, poliumoside (1) and verbascoside (2). Glycoside 1 was shown to inhibit mammalian DNApolymerases α,β,δ and ε with IC_<50> values of 42, 23, 35 and 9 μM, respectively, while those of glycoside 2 were all more than 100 μM.
- 日本生薬学会の論文
- 2003-08-20
著者
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Ito M
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Ito Michiho
北里大学 薬学部
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IIDA Akira
Graduate School of Pharmaceutical Sciences, Kyoto University
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Iida Akira
Graduate School Of Pharmaceutical Sciences Kyoto University
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Mizushina Yoshiyuki
Department of Nutritional Science, Kobe-Gakuin University
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KIUCHI Fumiyuki
Graduate School of Pharmaceutical Sciences, Kyoto University
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Ito Michiho
Graduate School Of Pharmaceutical Sciences Kyoto University
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YOSHIDA Horomi
Department of Nutritional Science, Kobe-Gakuin University
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SARSENBAEV Kanat
Institute Botany and Phytointroduction, National Academy of Science
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SARSRNBAEV Kanat
Institute of Botany and Phytointroduction
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Kiuchi Fumiyuki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Mizushina Yoshiyuki
Department Of Nutritional Science Kobe-gakuin University
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Honda G
Department Of Pharmacognosy Graduate School Of Pharmaceutical Sciences Kyoto University
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Honda Gisho
Graduate School Of Pharmaceutical Sciences Kyoto University
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Yoshida Horomi
Department Of Nutritional Science Kobe-gakuin University
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Mizushina Yoshiyuki
Department Of Nutritional Science Kobe Gakuin University
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Iidaa Akira
Graduate School of Pharmaceutical Sciences, Kyoto University
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Kiuchia Fumiyuki
Graduate School of Pharmaceutical Sciences, Kyoto University
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Kiuchia Fumiyuki
Graduate School Of Pharmaceutical Sciences Kyoto University
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Mizushina Yoshiyuki
Department of Applied Biological Science, Science University of Tokyo
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