Antiproliferative Activity of Rhinacanthus nasutus (L.) KURZ Extracts and the Active Moiety, Rhinacanthin C(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Rhinacanthus nasutus (L.) KURZ (Acanthaceae) is a shrub widely distributed in South China and India. In this study, the antiproliferative activity of the ethanol extract of root and aqueous extract of leaves of R. nasutus, and the supposed active moiety rhinacanthin C was assessed in vitro using the human cervical carcinoma cell line HeLa, its MDR1-overexpressing subline Hvr100-6, human prostate carcinoma PC-3 cells and human bladder carcinoma T24 cells. Rhinacanthin C was chemically synthesized and its content in the R. nasutus extracts was determined by HPLC with a photodiode array detector. The antiproliferative activity of the R. nasutus extracts was also assessed in vivo using sarcoma 180-bearing mice. It was suggested that 1) the in vitro antiproliferative activity of rhinacanthin C was comparable with or slightly weaker than that of 5-FU, 2) rhinacanthin C showed antiproliferative activity for MDR1-overexpressing Hvr100-6 cells, similarly to parent HeLa cells, 3) the in vitro antiproliferative activity of the ethanol extract of root R. nasutus was due to rhinacanthin C, whereas that of the aqueous extract of leaves ofR. nasutus was due to constituents other than rhinacanthin C, and 4) both of the R. nasutus extracts showed in vivo antiproliferative activity after oral administration once daily for 14 d.
- 社団法人日本薬学会の論文
- 2004-07-01
著者
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Kimura Takashi
Department of Neurology, National Douhoku Hospital
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竹本 佳司
Faculty Of Pharmaceutical Sciences Osaka University
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Nakamura T
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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SAKAEDA Toshiyuki
Department of Hospital Pharmacy, Kobe University School of Medicine
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Kamigaki Takashi
Kobe University Graduate School of Medicine
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飯田 彰
京大 院 薬
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Hirai Midori
Kobe university school of medicine
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Kimura T
Kobe University Graduate School Of Medicine
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GOTOH AKINOBU
Department of Urology, Kobe University School of Medicine
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Hirai M
Kobe Pharmaceutical University
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Hirai M
Kobe Pharmaceutical Univ.
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WADA Atsushi
Department of Clinical Pharmacy, Kobe Pharmaceutical University
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Kimachi Tetsutaro
神戸大学医学部附属医学研究国際交流センター
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Kimachi Tetsutaro
Faculty Of Pharmaceutical Sciences Kyoto University
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Kimachi Tetsutaro
Faculty Of Pharmaceutical Sciences Mukogawa Women's University
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Takemoto Yoshiji
Graduate School Of Pharmaceutical Sciences Kyoto Univ. Yoshida Sakyo-ku Kyoto 606-8501 Jpn
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Takemoto Yoshiji
Faculty Of Pharmaceutical Sciences Osaka University
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Takemoto Y
Graduate School Of Pharmaceutical Sciences Kyoto University
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SHIRAKAWA Toshiro
Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine
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WADA Yoshitaka
Department of Organs Therapeutics, Faculty of Medicine, Kobe University Graduate School of Medicine
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IIDA Akira
Graduate School of Pharmaceutical Sciences, Kyoto University
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IWAKAWA Seigo
Kobe Pharmaceutical University
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TOMITA Hisako
Kobe Pharmaceutical University
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Nakajima Takahiro
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Iida A
Graduate School Of Pharmaceutical Sciences Kyoto University
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Iida Akira
Faculty Of Pharmaceutical Sciences Kyoto University
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Iida Akira
Graduate School Of Pharmaceutical Sciences Kyoto University
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Okumura K
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Wada A
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Wada Atsushi
Department Of Cardiovascular Medicine Chigasaki Municipal Hospital
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Takemoto Yoshiji
Graduate School Of Pharmaceutical Sciences Kyoto Univ.
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Takara Kohji
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Takara Kohji
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Gotoh A
Division Of Urology Department Of Organ Therapeutics Faculty Of Medicine Kobe University Graduate Sc
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy Kobe University Hospital
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IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
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Gotoh Akinobu
Departments Of Clinical Genetics And International Center For Medical Research School Of Medicine:di
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Shirakawa T
Kobe University School Of Medicine
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Shirakawa Toshiro
Department Of Urology Kobe University School Of Medicine
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Iwakawa S
Department Of Cardiology Miki
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Kita Tomoko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Wada Yoshitaka
Department Of Urology For Medical Research Kobe University School Of Medicine
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Okumura Katsuhiko
Department Of Hospital Pharmacy Kyoto Pharmaceutical University:department Of Hospital Pharmacy Kobe
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Shirakawa Toshiro
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Shinobu Ichikawa
Department Of Cardiology Miki
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Wada Yoshitaka
Department Of Applied Chemistry Graduate School Of Science And Engineering Tokyo Institute Of Techno
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura T
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakai T
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Koishi Tomokazu
Department Of Hospital Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nakamura Takatoshi
Faculty Of Pharmaceutical Sciences Nagoya City University
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Ichikawa Shinobu
Department Of Cardiology Miki City Hospital
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Kimura Takashi
Department Of Medicine And Molecular Science Division Of Frontier Medical Science Programs For Biome
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Wada Atsushi
Department Of Cardiology Chigasaki Municipal Hospital
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Nakamura Tsutomu
Department Of Chemistry Faculty Of Science Faculty Of Agriculture Kyoto Unviersity
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Kimura Takashi
Department Of Comparative Pathology Faculty Of Veterinary Medicine Hokkaido University
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KIMURA Takashi
Department of Cardiovascular, Respiratory and Metabolic Medicine Graduate School of Medicine, Kagoshima University
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