Effect of Serum Triglyceride Concentration on the Fluctuation of Whole Blood Concentration of Cyclosporin A in Patients
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概要
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The methodology to distinguish the patients showing consideravle fluctuation of the whole blood concentration of cyclosporin A(CYA)was investigated from a viewpoint of laboratory test values. First, we retrospectively ecxamined the CYA trough blood concentrations monitored continuously. The patients were classfied into three groups by the fluctuation of CYA trough blood concentrations during the examination period(C_<max>/C_<min>) : Group 1(C_<max>/C_<min>=100-200% ; n=21), Group 2(C_<max>/C_<min>=200-300% ; n=25), and Group 3(C_<max>/C_<min>=more than 300% ; n=32). In the laboratory tests ezamined, the serum triglyceride concentrations were considerably different among the groups, and it was the highest in Group3. Next, to elucidate the effect of serum triglyceride concentration on the CYA blood concentration, in vivo pharmacokinetic studies after single intravenous or repetitice oral administration of CYA were conducted in the model rats with pseudo-hypertriglyceridemia, hypocythemia, and abute renal failure. Only in pseudo-hypertriglyceridemia rats, the CYA blood concentration after a single intravenous injection was signficantly higher than that in normnal rats because of the restriction of CYA distribution to the extravascular of CYA trough blood concentration agter repetitive oral administration. Taken together, the fluctuation of CYA trough blood concentrations observed in the clinical situation could be due to the fluctuation of serum triglyceride concentration, and the patients with such fluctuation of serum triglyceride concentrations might also be distingushable by the higher concentration of serum triglyceride in laboratory tests.
- 公益社団法人日本薬学会の論文
- 2001-06-01
著者
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HIRAI Midori
Department of Clinical Pharmacy, Kobe Pharmaceutical University
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Nakamura T
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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NAKAMURA Tsutomu
Department of Hospital Pharmacy, Kobe University School of Medicine
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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SAKAEDA Toshiyuki
Department of Hospital Pharmacy, Kobe University School of Medicine
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Kasuga Masato
Department Of Hospital Pharmacy School Of Medicine Kobe University
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KAKUMOTO Mikio
Department of Biochemistry, Gifu Pharmaceutical University
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Kakumoto M
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Kakumoto Mikio
Department Of Biochemistry Gifu Pharmaceutical University
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Hirai M
Kobe Pharmaceutical University
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Hirai M
Kobe Pharmaceutical Univ.
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Nishiguchi Kohshi
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Okumura K
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Sakaeda Toshiyuki
Department Of Hospital Pharmacy Kobe University Hospital
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Hirai Midori
Department Of Applied Biology And Chemistry Faculty Of Applied Bio-science Tokyo University Of Agric
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Shirakawa T
Kobe University School Of Medicine
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YAMASHITA Kazuhiko
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Homma M
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Kawahara Yuko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Nishiguchi K
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Nishiguchi Kohshi
Department Of Clinical Pharmacy Faculty Of Pharmaceutical Sciences Kyoto Pharmaceutical University
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Nishiguchi Kohshi
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Horinouhi Masanori
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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NAGASHIRO Kazumi
Department of Hospital Pharmacy, School of Medicine, Kobe University
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OHMICHI Rumi
Department of Hospital Pharmacy, School of Medicine, Kobe University
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Okumura Katsuhiko
Department Of Hospital Pharmacy Kyoto Pharmaceutical University:department Of Hospital Pharmacy Kobe
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Nakamura Tsutomu
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Ohmichi Rumi
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Nakamura Takeshi
Department Of Gastroenterological Surgery Kobe University Graduate School Of Medical Sciences
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Nakamura T
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Sakai T
Department Of Internal Medicine And Gastrointestinal Endoscopy Saga Medical School
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Homma Masato
Department Of Pharmaceutical Sciences Graduate School Of Comprehensive Human Sciences University Of
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Yamashita K
Department Of Clinical Pharmacy Kobe Pharmaceutical University
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Nagahiro Kazumi
Department Of Hospital Pharmacy Kobe University School Of Medicine
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Yamashita Kazuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Nakamura Tsutomu
Department Of Chemistry Nara Womens University
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Yamashita Kazuhiko
Department Of Clinical Evaluation Of Pediatrics Kobe University Graduate School Of Medicine
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Nagashiro Kazumi
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Yamashita Kazuhiko
Department Of Agricultural Sciences Faculty Of Agriculture Okayama University
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Nakamura Tsutomu
Department Of Chemistry Faculty Of Science Faculty Of Agriculture Kyoto Unviersity
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Kaneko M
Department Of Pharmacology Faculty Of Pharmaceutical Sciences Chiba Institute Of Science
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Kaneko Masayuki
千葉科学大学
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