Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa : Effect of Gastric Ulceration

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概要

• 論文の詳細を見る

• The effect of experimental ulcers on the binding of human epidermal growth factor (hEGF), β-urogastrone, to plasma membranes isolated from rat gastric mucosa was studied in order to develop hEGF as an anti-ulcer drug. The binding of [^<125>I] hEGF to the gastric plasma membranes was significantly decreased 1 h after treatment with aspirin (300 mg/kg) and after 12 h of water-immersion stress. However, the number of EGF binding sites was increased 12 h after aspirin administration. There was little change in the binding of [^<125>I] insulin to the gastric plasma membranes in response to water-immersion stress. These results indicate that changes in EGF binding to its receptors occur on plasma membranes of the rat gastric mucosa during ulcer.

• 公益社団法人日本薬学会の論文

著者

• OKUMURA Katsuhiko

  Department of Hospital Pharmacy, Kobe University School of Medicine

• HORI Ryohei

  Department of Pharmacy, Kyoto University Hospital

• IWAKAWA Seigo

  Kobe Pharmaceutical University

• SAITO Yoshihiro

  Department of Radiology and Radiation Oncology, Gunma University School of Medicine

• IWAKAWA Seigo

  Department of Pharmaceutics, Kobe Pharmaceutical University

• Iwakawa S

  Department Of Cardiology Miki

• Iwakawa Seigo

  Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un

• Okumura K

  Department Of Pharmacy Kobe University School Of Medicine

• Hori R

  Kinki Univ. Osaka Jpn

• Hori Ryohei

  Department Of Pharmacy Kyoto University Hospital

• Hori Ryohei

  Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.

• Saito Yoshihiro

  Department Of Bio-analytical Chemistry Osaka University Of Pharmaceutical Sciences

• Okumura Katsuhiko

  Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine

• Hori Ryohei

  Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un

• Shinobu Ichikawa

  Department Of Cardiology Miki

• Nomura Hisashi

  Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un

• Okumura K

  Department Of Hospital Pharmacy School Of Medicine Kobe University

• Hori Ryohei

  Kyoto University School Of Medicine Kyoto

• Okumura Katsuhiko

  Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un

• Ichikawa Shinobu

  Department Of Cardiology Miki City Hospital

• Okumura Katsuhiko

  Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University

• Okumura Katsuhiko

  Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre

• Saito Yoshihiro

  Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre

• Saito Yoshihiro

  Department Of Analytical Chemistry Osaka University Of Pharmaceutical Sciences

• Hori Ryohei

  Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un

• Saito Yoshihiro

  Department Of Aeronautics And Astronautics

• Iwakawa Seigo

  Department of Cardiology, Miki

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