Regulation of Epidermal Growth Factor Receptors in Rat Gastric Mucosa : Effect of Gastric Ulceration
スポンサーリンク
概要
- 論文の詳細を見る
The effect of experimental ulcers on the binding of human epidermal growth factor (hEGF), β-urogastrone, to plasma membranes isolated from rat gastric mucosa was studied in order to develop hEGF as an anti-ulcer drug. The binding of [^<125>I] hEGF to the gastric plasma membranes was significantly decreased 1 h after treatment with aspirin (300 mg/kg) and after 12 h of water-immersion stress. However, the number of EGF binding sites was increased 12 h after aspirin administration. There was little change in the binding of [^<125>I] insulin to the gastric plasma membranes in response to water-immersion stress. These results indicate that changes in EGF binding to its receptors occur on plasma membranes of the rat gastric mucosa during ulcer.
- 公益社団法人日本薬学会の論文
著者
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
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IWAKAWA Seigo
Kobe Pharmaceutical University
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SAITO Yoshihiro
Department of Radiology and Radiation Oncology, Gunma University School of Medicine
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IWAKAWA Seigo
Department of Pharmaceutics, Kobe Pharmaceutical University
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Iwakawa S
Department Of Cardiology Miki
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Iwakawa Seigo
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Okumura K
Department Of Pharmacy Kobe University School Of Medicine
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Hori R
Kinki Univ. Osaka Jpn
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.
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Saito Yoshihiro
Department Of Bio-analytical Chemistry Osaka University Of Pharmaceutical Sciences
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Shinobu Ichikawa
Department Of Cardiology Miki
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Nomura Hisashi
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Hori Ryohei
Kyoto University School Of Medicine Kyoto
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Ichikawa Shinobu
Department Of Cardiology Miki City Hospital
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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Saito Yoshihiro
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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Saito Yoshihiro
Department Of Analytical Chemistry Osaka University Of Pharmaceutical Sciences
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Saito Yoshihiro
Department Of Aeronautics And Astronautics
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Iwakawa Seigo
Department of Cardiology, Miki
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