MECHANISMS OF PHARMACOKINETIC INTERACTION BETWEEN AJMALINE AND QUINIDINE IN RATS
スポンサーリンク
概要
- 論文の詳細を見る
In order to elucidate the mechanism of ajmaline-quinidine interaction previously observed in humans, the effects of quinidine on pharmacokinetics of ajmaline were investigated in rats. Concurrent oral administration of 10 mg/kg of quinidine markedly increased the plasma concentration of ajmaline at a dose of 2 mg/kg. On the other hand, it did not affect the pharmacokinetics of ajmaline after intravenous dose. The availability of ajmaline after oral dose showed an increase from 13% to nearly 100% by the presence of quinidine, which suggests a change in the presystemic clearance of ajmaline. In fact, when ajmaline was administered into the intestinal loop, its concentration in mesenteric venous plasma increased approximately 5-fold by the combination with quinidine. Furthermore, quinidine delayed the elimination rate of ajmaline from the perfused rat liver. These results indicate that quinidine prevents presystemic elimination of ajmaline in the intestine and liver, and increases the systemic availability of ajmaline.
- 公益社団法人日本薬学会の論文
著者
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Kawai Chuichi
京都大学 第3内科
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HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
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Kawai C
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
Department of Cardiology, Takeda General Hospital
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Kawai Chuichi
Department Of 3rd Internal Medicine Faculty Of Medicine Kyoto University
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Yamada Kazushi
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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Yasuhara M
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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Okumura K
Department Of Pharmacy Kobe University School Of Medicine
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Hori R
Kinki Univ. Osaka Jpn
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital
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Hori Ryohei
Department Of Pharmacy Kyoto University Hospital:product Development Laboratory Sankyo Co. Ltd.
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Sakurai Tsunetaro
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Hori R
Laboratory Of Cell Structure And Function Wood Research Institute Kyoto University
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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Hori Ryohei
Kyoto University School Of Medicine Kyoto
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Yamaoka K
Moa Health Science Foundation Life Science Institute
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Okumura Katsuhiko
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Okumura Katsuhiko
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University:(present Addre
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Yatsuzuka Atsushi
Department Of Pharmacy:department Of Internal Medicine Kyoto University Hospital Faculty Of Medicine
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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