Pathogenesis of Myocardial Injury in Myocarditis and Cardiomyopathy : 54th Annual Scientific Session of the Japanese Circulation Society
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概要
- 論文の詳細を見る
The pathogenesis of myocardial cell injury in myocarditis and cardiomyopathy was investigated. The presence of viral genomes in the murine heart in experimental coxsackievirus B3 myocarditis was studied by Northern blotting analysis using a ^<32>P-labeled cDNA probe from the 5' end sequence. The strongest signal of positive autoradiograms was always at about 7.4 kilobases, corresponding to the size of the complete genome of the virus. Successive infections with coxsackievirus and encephalomyocarditis (EMC) virus infection showed simultaneous acute myocarditis and healed myocarditis, and the results suggest that successive virus infections cause additional myocardial damage, and develop lesions similar to chronic myocarditis or dilated cardiomyopathy. Antiheart auto-antibody, induced during EMC virus infection, reacted predominantly with myosin. Indium-111 antimyosin scintigraphy showed positive in some of the patients with cardiomyopathy, and the uptake was inversely correlated with left ventricular function. When mice were injected with antimyosin antibody, mouse immunoglobulin G was detected in hearts in the chronic stage of EMC virus myocarditis, in myocytes surrounding fibrosis and calcification, suggesting deposition of antimyosin antibody. Although further study is necessary to clarify the mechansim of uptake of antimyosin in cardiomyopathy, antimyosin anti-body may accumulate in viable myocytes with ongoing degeneration as well as in necrosis.
- 社団法人日本循環器学会の論文
- 1991-11-20
著者
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Kawai Chuichi
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
京都大学 第3内科
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Kawai Chuichi
京都大学 医学研究科循環器内科学
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Kawai C
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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MATSUMORI AKIRA
The Third Department of Internal Medicine
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YAMADA TAKEHIKO
The Third Department of Internal Medicine
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Kawai Chuichi
The Third Division Department Of Internal Medicine. Faculty Of Medicine Kyoto University
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Yamada Takehiko
Department Of Cardiology Daio Municipal Hospital
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Okada Ikutaro
The Third Division, Department of Internal Medicine
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MARUYAMA SHINGO
The Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Okada Ikutaro
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Yamada Takehiko
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawai Chuichi
The Third Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Yamada Takehiko
Department Of Cardiovascular Medicine Graduate School Of Medicine
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Maruyama Shingo
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kawai Chuichi
Division Of Cardiology Kyoto Takeda Hospital
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