PATHOPHYSIOLOGICAL STUDIES ON HYPERTENSION INDUCED IN RATS BU KIDNEY EXTRACT AND SALT

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概要

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• The renin-angiotensin-aldosterone system, electrolyte and water balance, body fluid, and neurogenic tone and reactivity of the vasculature were studied in hypertension induced in uninephrectomized rats by repeated injection of renin-rich kidney extract and 1% saline drinking. The control rats were injected with physiological saline. Various measurements were made in conscious rats on the 10th day of the treatment. As compared with the control, plasma renin concentration and serum sodium increased significantly, while plasma aldosterone and renal excretory function did not differ. Blood volume (BV) expressed as per body weight increased significantly, but absolute BV, absolute or body weight-related plasma volume and hematocrit were not significantly different. The hypotensive effect of 1-Sar-8-Ile-angiotensin II was negligible 12 hours after the preceding injection of kidney extract. It was small but significant 1 hour after the injection. Increase in water turn-over and fractional sodium excretion occurred during the development of hypertension. Spironolactone did not significantly modify the developmental course. We observed increased depressor response to hexa-methonium and increased reactivities to noradrenaline and angiotensin II (A II); these response curves relatively resembled those of spontaneously hypertensive rats. Hypertensive vascular changes were seen in the kidney and heart by histology. Thus, it as suggested that a direct vasculat action of A II played a partial role in this hypertensive process while aldosterone played little role. The significance of BV increase and possible contribution of A II's other actions were discussed.

• 社団法人日本循環器学会の論文
• 1980-01-20

著者

• Hara Akira

  First Department Of Internal Medicine. Fukui Medical School

• Kawai C

  The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group

• Hara A

  First Department Of Internal Medicine. Fukui Medical School

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• HARA AKIRA

  Third Department of Medicine, Kyoto University, School of Medicine

• PAK CHUN

  Third Division, Department of Internal Medicine, Faculty of Medicine

• YAMAMOTO JIN

  Third Division, Department of Internal Medicine

• MATSUNAGA MASATO

  Third Division, Department of Internal Medicine

• KOMURO TETSUO

  Department of Pharmacy

• PARK CHUNO

  Third Division, Department of Internal Medicine

• SAITO NOBORU

  Clinical Nutrition Laboratory, Kyoto University Hospital

• OGINO KOICHI

  Third Division, Department of Internal Medicine

• MATSUNAGA Masato

  Kyoto Univ.

• Hirakawa Akina

  From The Third Division Department Of Internal Medicine Kyoto University

• Hara A

  Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University

• Hara Akira

  Shonan Institute Of Technology

• Yamamoto Jin

  National Cardiovascular Center Researchinstitute

• Yamamoto Jjn

  Dept. Of Intern. Med. National Himeji Hosp.

• Ogino Koichi

  The Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Ogino Koichi

  Iii Division Department Of Medicine Kyoto University Hospital

• Ogino Koichi

  The 3rd Division Department Of Internal Medicine School Of Medicine Kyoto University

• Pak C

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Yamamoto Jin

  National Himeji Hosp. Dept. Of Intern. Med

• Ogino Koichi

  Third Division Department Of Internal Medicine

• Ogino Koichi

  3rd Dept. Of Intern. Med. Kyoto Univ.

• Hirakawa Akiha

  3rd Dept. Of Intern. Med. Kyoto Univ.

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology

• Ogino Koichi

  3rd Division Dept. Of Intern. Med. Kyoto Univ. Sch. Of Med.

• Matsunaga Masato

  Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology

• Hara Akira

  From The Third Division Department Of Internal Medicine Kyoto University

• Matsunaga Masato

  The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Yamamoto Jin

  Third Division Department Of Internal Medicine

• Ogino Koichi

  Maekatva Clinic Kyoto University Hospital

• Saito Noboru

  Clinical Nutrition Laboratory Kyoto University Hospital

• Kawai Chuichi

  3rd Div. Dept Of Intern Med. Kyoto Univ

• Kono Tsuyoshi

  The Second Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Hirakawa Akina

  3rd Medical Clinic Faculty Of Medicine Kyoto University

• Hara Akira

  Third Department Of Medicine Kyoto University School Of Medicine

• Kawai Chuichi

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Matsunaga Masato

  Central Clinical Laboratories Kyoto Univ. Hosp.

• Saito Noboru

  3rd Div. Dept. Of Intern. Med. Kyoto Univ. Hosp.

• Komuro Tetsuo

  Department Of Pharmacy Kyoto University Hospital Kyoto University

• Ogino Koichi

  Third Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology Kyoto University

• Saito Noboru

  Clinical Nutrition Laboratory Kyoto Univ. Hosp.

• YAMAMOTO Jin

  Third Department of Internal Medicine, Faculty of Medicine, Kyoto University

• MATSUNAGA Masato

  Third Department of Internal Medicine, Faculty of Medicine, Kyoto University

• HARA Akira

  Third Department of Internal Medicine, Faculty of Medicine, Kyoto University

• SAITO Noboru

  Clinical Nutrition Laboratory and Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University

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