Glucan-Binding Activity of Silkworm 30-kDa Apolipoprotein and Its Involvement in Defense against Fungal Infection

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概要

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• The silkworm Bombyx mori 30-kDa lipoproteins (6G1 and 19G1), major components of the hemolymph, were shown to bind to glucans. 6G1 apolipoprotein was expressed as a fusion protein with glutathione S-transferase in Escherichia coli and assayed for its binding activity. The purified recombinant 6G1 apolipoprotein specifically bound to β-glucan, but not to chitin, mannan, peptidoglycan, or oligosaccharide chains on glycoproteins. The β-glucan binding of the recombinant 6G1 was inhibited by laminaribiose and laminarin, a soluble glucan, but not by lipopolysaccharide or insect blood sugar, trehalose at physiological concentration. Furthermore, the recombinant 6G1 was shown to participate in the activation of prophenoloxidase cascade and to interfere with hyphal growth of the entomopathogenic fungus Paecilomyces tenuipes, injected into pupae of B. mori. These results suggest that 6G1 lipoprotein plays a role in the protection of B. mori against invading fungi.

• 社団法人 日本農芸化学会の論文
• 2005-06-23

著者

• Kawachi Ichiro

  Laboratory Of Biological Chemistry Department Of Applied Biological Chemistry Faculty Of Agriculture

• UJITA Minoru

  Laboratory of Biological Chemistry, Department of Applied Biological Chemistry, Faculty of Agricultu

• KATSUNO Yosuke

  Laboratory of Biological Chemistry, Department of Applied Biological Chemistry, Faculty of Agricultu

• UENO Yoshinori

  Institute of Genetic Resources, Kyushu University

• BANNO Yutaka

  Institute of Genetic Resources, Kyushu University

• FUJII Hiroshi

  Institute of Genetic Resources, Kyushu University

• HARA Akira

  Laboratory of Biological Chemistry, Department of Applied Biological Chemistry, Faculty of Agricultu

• Hara Akira

  First Department Of Internal Medicine. Fukui Medical School

• Ujita M

  Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University

• Hara A

  First Department Of Internal Medicine. Fukui Medical School

• Hirakawa Akina

  From The Third Division Department Of Internal Medicine Kyoto University

• Hara A

  Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University

• Hara Akira

  Shonan Institute Of Technology

• Fujii Hajime

  Institute Of Natural Medicine University Of Toyama

• Banno Y

  Kyushu Univ. Fukuoka Jpn

• Fujii Hiroshi

  Dep. Of Bioscience And Biotechnology Shinshu Univ.

• Katsuno Yosuke

  Laboratory Of Biological Chemistry Department Of Applied Biological Chemistry Faculty Of Agriculture

• Ueno Yoshinori

  Institute Of Genetic Resources Faculty Of Agriculture Kyushu University

• Hirakawa Akiha

  3rd Dept. Of Intern. Med. Kyoto Univ.

• Ujita Minoru

  Laboratory Of Biological Chemistry Department Of Applied Biological Chemistry Faculty Of Agriculture

• Fujimoto Hirofumi

  Division Of Radiological Protection And Biology National Institute Of Infectious Diseases

• Hara Akira

  Laboratory Of Biochemistry Gifu Pharmaceutical University

• Hara Akira

  From The Third Division Department Of Internal Medicine Kyoto University

• Hirakawa Akina

  3rd Medical Clinic Faculty Of Medicine Kyoto University

• FUJII Hiroshi

  Yamagata Agricultural Experimental Station, Shounai Branch

• Banno Yutaka

  Institute Of Genetic Resources Faculty Of Agriculture Kyushu University Graduated School

• Fujii H

  Laboratory Of Insect Genetic Resources Faculty Of Agriculture Kyushu University

• Fujii H

  Yamagata Agricultural Experimental Station Shounai Branch

• Hara Akira

  Laboratory Of Biochemistry And Nutritional Chemistry:(present Address)faculty Of Agriculture Meijo U

• Fujii Hiroshi

  Institute For Life Support Technology Yamagata Technopolis Foundation

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