PREVENTION OF NEPHROSCLEROSIS AND CARDIAC HYPERTROPHY BY CAPTOPRIL TREATMENT OF SPONTANEOUSLY HYPERTENSIVE RATS

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概要

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• The relationship between hypertension and cardiovascular damage was assessed in three groups of spontaneously hypertensive rats (SHR): 1. stroke prone SHR (SHR-SP) treated orally with an angiotensin I converting enzyme inhibitor (captopril) (100-400 mg/L in the drinking water) from 6 to 35 weeks of age, 2. SHR-SP maintained on tap water until 30 weeks of age, 3. stroke resistant SHR (SHR-SR) maintained on tap water. The controls were Wister Kyoto rats (WKY) maintained on tap water. Captopril-treated SHR-SP showed blood pressure lower than that of untreated SHR-SP, similar to SHR-SR. The ratio of heart weight to body weight was 0.55% in SHR-SP, 0.39% in captopril-treated SHR-SP, 0.46% in SHR-SR, and 0.39% in WKY. The kidneys of SHR-SP showed glomerular sclerosis, glomerular fibrosis, tubular casts, interstitial cell infiltration and vascular wall thickening or hyperplasia of the small arteries and arterioles. The severe glomerular sclerosis was mostly distributed in the inner and middle portions of cortex. Immunohistological study showed IgG, C3 and fibrinogen in the glomeruli and arterioles in SHR-SP. In captopril-treated SHR-SP, similar to SHR-SR, only minor histological changes were seen and there was no deposition of IgG, C3 or fibrinogen. No changes were seen in WKY. Thus, it was concluded that nephrosclerosis and cardiac hypertrophy in SHR-SP are prevented by captopril. The role of the renin-angiotensin and kallikrein-kinin systems in organ pathogenesis in SHR-SP is discussed.

• 社団法人日本循環器学会の論文
• 1986-02-20

著者

• NAGAI Hiroyuki

  Department of Physics, Faculty of Science, Shinshu University

• Hara Akira

  First Department Of Internal Medicine. Fukui Medical School

• Nagai H

  Department Of Physics Faculty Of Science Shinshu University

• Hara A

  First Department Of Internal Medicine. Fukui Medical School

• Kawai Chuichi

  Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• OHASHI HIROMI

  Third Division, Department of Internal Medicine, Faculty of Medicine

• MATSUNAGA MASATO

  Collage of Medical Technology, Kyoto University

• YOSHIDA HARUYOSHI

  Third Division, Department of Internal Medicine, Faculty of Medicine

• NAGAI HIROYUKI

  Third Division, Department of Internal Medicine, Faculty of Medicine

• PAK CHUN

  Third Division, Department of Internal Medicine, Faculty of Medicine

• MATSUNAGA Masato

  Kyoto Univ.

• Hirakawa Akina

  From The Third Division Department Of Internal Medicine Kyoto University

• Hara A

  Department Of Applied Biological Chemistry Faculty Of Agriculture Meijo University

• Hara Akira

  Shonan Institute Of Technology

• Pak C

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Nagai Hiroyuki

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Hirakawa Akiha

  3rd Dept. Of Intern. Med. Kyoto Univ.

• Pak Chun

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Matsunaga Masato

  Third Division Department Of Internal Medicine Faculty Of Medicine And College Of Medical Technology

• Hara Akira

  From The Third Division Department Of Internal Medicine Kyoto University

• Matsunaga Masato

  The 3rd Division Department Of Internal Medicine Faculty Of Medicine Kyoto University

• Hirakawa Akina

  3rd Medical Clinic Faculty Of Medicine Kyoto University

• Oohashi Hiromi

  Third Division Department Of Internal Medicine Faculty Of Medicine

• NAGAI Hiroyuki

  Physics Department College of Liberal Arts Kyushu Sangyo University

• Kawai Chuichi

  Third Department Of Internal Medicine Kyoto University Faculty Of Medicine

• Yoshida Haruyoshi

  Third Division Department Of Internal Medicine Faculty Of Medicine

• Matsunaga Masato

  Central Clinical Laboratories Kyoto Univ. Hosp.

• PAK Chun

  Third Department of Internal Medicine, Faculty of Medicine, Kyoto University

• NAGAI Hiroyuki

  Department of Physics, College of Liberal Arts, Kyushu Sangyo University

• Hara Akira

  First Department of Internal Medicine, Fukui-Medical School

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