Characterization of an Oligomeric Carbonyl Reductase of Dog Liver : Its Identity with Peroxisomal Tetrameric Carbonyl Reductase(Biochemistry)
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概要
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Dog liver contains an oligomeric NADPH-dependent carbonyl reductase (CR) with substrate specificity for alkyl phenyl ketones, but its endogenous substrate and primary structure remain unknown. In this study, we examined the molecular weight and substrate specificity of the enzyme purified from dog liver. The enzyme is a ca. 100-kDa tetramer composing of 27-kDa subunit, and reduces all-trans-retinal and α-dicarbonyl compounds including isatin, which are substrates for pig peroxisomal tetrameric carbonyl reductase (PTCR). In addition, the dog enzyme resembles pig PTCR in inhibitor sensitivity to flavonoids, myristic acid, lithocholic acid, bromosulfophthalein and flufenamic acid. Furthermore, the amino acid sequence of dog CR determined by protein sequencing and cDNA cloning was 84% identical to that of pig PTCR and had a C-terminal peroxisomal targeting signal type 1, Ser-His-Leu. The immunoprecipitation using the anti-pig PTCR antibody shows that the dog enzyme is a major form of soluble NADPH-dependent all-frans-retinal reductase in dog liver. Thus, dog oligomeric CR is PTCR, and may play a role in retinoid metabolism as a retinal reductase.
- 社団法人日本薬学会の論文
- 2007-09-01
著者
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HARA Akira
Laboratory of Biological Chemistry, Department of Applied Biological Chemistry, Faculty of Agricultu
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Ishikura S
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Ishikura Shuhei
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Ishikura Syuhei
Hospital For Sick Children
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ENDO Satoshi
Laboratory of Biochemistry, Gifu Pharmaceutical University
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MATSUNAGA Toshiyuki
Laboratory of Biochemistry, Gifu Pharmaceutical University
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Hara Akira
岐阜薬科大学 生化学研究室
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Nagano Makoto
Laboratory Of Biochemistry Gifu Pharmaceutical University
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ABE Hiroko
Laboratory of Biochemistry, Gifu Pharmaceutical University
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IMAMURA Yorishige
Graduate School of Pharmaceutical Sciences, Kumamoto University
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Imamura Yorishige
Graduate School Of Pharmaceutical Sciences Kumamoto University
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Hara Akira
Lab. Of Biochemistry Gifu Pharmaceutical Univ.
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Hara Akira
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Abe Hiroko
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Matsunaga Toshiyuki
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Hara Akira
Laboratory Of Biochemistry And Nutritional Chemistry:(present Address)faculty Of Agriculture Meijo U
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