Properties and Tissue Distribution of Mouse Monomeric Carbonyl Reductase
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概要
- 論文の詳細を見る
We previously cloned a cDNA for mouse cerebellum carbonyl reductase which shows more than 81% homology to the cDNAs for monomeric carbonyl reductases of the rat, rabbit and human, and for pig 20β-hydroxy-steroid dehydrogenase. In the present study, we expressed the recombinant monomeric enzyme (34 kDa and pI 8.3) from the cDNA and compared its properties with the recombinant human enzyme. The mouse and human enzymes showed similar functional properties, although they differed in kinetic constants for carbonyl substrates and in inhibitor sensitivity. Both enzymes lacked glutathione S-transferase activity. Western blot and reversetranscription-polymerase chain reaction analyses showed that the enzyme protein and its mRNA are expressed in various mouse tissues.
- 公益社団法人日本薬学会の論文
- 1998-08-15
著者
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MATSUURA Kazuya
Laboratory of Biochemistry, Gifu Pharmaceutical University
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Ishikura Shuhei
Laboratory Of Biochemistry Gifu Pharmaceutical University
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Hara Akira
Laboratory Of Biochemistry Gifu Pharmaceutical University
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YAMAMOTO Yutaka
Laboratory of Biochemistry, Gifu Pharmaceutical University
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WEI Jianjun
Department of Pathology and Laboratory Medicine, Indiana University School of Medicine
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HODES M.E.
Department of Phathology and Laboratory Medicine, Indiana University School of Medicine
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Hara Akira
Laboratory Of Biochemistry And Nutritional Chemistry:(present Address)faculty Of Agriculture Meijo U
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WEI Jianjun
Department of Environmental Engineering, Beijing University of Chemical Technology
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