SERUM FROM PATIENTS WITH RESTENOSIS AFTER PERCUTANEOUS TRANSLUMINAL CORONARY ANGIOPLASTY STIMULATES PROLIFERATION OF BOVINE VASCULAR SMOOTH MUSCLE CELLS UNDER LOW EXTRACELLULAR CALCIUM CONDITION
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概要
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We compared the effects on the proliferation of bovine vascular smooth muscle cells (VSMC) of serum from 36 patients without restenosis (group A). and 21 patients with restenosis (group B) after percutaneous transluminal coronary angioplasty (PTCA). Baseline characteristics were similar in both groups. except for the greater number of patients with unstable angina at the time of PTCA (52 vs 22%, p=0.020) and the shorter interval between PTCA and repeat angiography in group B (106±30 vs 153±112 days, p=0.022). Cultured bovine VSMC were stimulated with patient serum (5%) obtained at repeat angiography in either Ca^<2+>-containing or Ca^<2+>-free culture medium. DNA synthesis was assessed by [^3H]thymidine, incorporation. The following indices of VSMC proliferation were used: S(+)= [^3H]thymidine uptake stimulated by 5% serum in Ca^<2+>-containing medium/[^3H]thymidine uptake stimulated by 5% fetal calf serum (FCS) in Ca^<2+>-containing medium. S(-)=[^3H]thymidine uptake stimulated by 5% serum in Ca^<2+>-free medium/[^3H]thymidine uptake stimulated by 50% FCS in Ca^<2+>-free medium, and D=S(-)-S(+). D represented the preserved DNA synthesis in Ca^<2+>-deprived medium. S(-) was lower than S(+) in group A (1.35±0.56 vs 1.57±0.58, p<0.0001), whereas it was higher than S( +) in group B (1.64±0.66 vs 1.50±0.58, p=0.010). D was significantly higher in group B than in group A (0.14±0.23 vs -0.22±0.28, p<0.0001), and was not associated with any continuous variables including serum calcium level on univariate regression analysis. However, multivariate analysis revealed unstable angina as an independent variable for D. Thus, it is suggested that serum from patients with restenosis stimulates VSMC proliferation while not requiring as much extracellular Ca^<2+> as serum from those without restenosis. This serum property appears to be associated with the angina pattern at PTCA. This finding concerning serum in patients with restenosis may contribute to the understanding of the pathophysiological mechanisms underlying restenosis.
- 社団法人日本循環器学会の論文
- 1991-06-20
著者
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Kawai Chuichi
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
京都大学 第3内科
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Kawai Chuichi
京都大学 医学研究科循環器内科学
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Kawai C
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Hattori R
Jj-mic(b) : Japan Multicenter Investigation For Cardiovascular Diseases (b) Study Group
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HATTORI RYUICHI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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YUI YOSHIKI
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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SHIROTANI MANABU
Third Division, Department of Internal Medicine, Faculty of Medicine, Kyoto University
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Kawai Chuichi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Yui Yoshiki
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Hattori Ryuichi
Third Division Department Of Internal Medicine Faculty Of Medicine
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Shirotani Mamoru
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Shirotani Manabu
Dept. Of Cardiology Kokura Memorial Hosp.
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Yazaki Yoshio
The Third Dept. Of Medicine University Of Tokyo
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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