RELATION BETWEEN MYOGLOBIN AND CARDIAC DYSFUNCTION IN MYOCARDITIS : Immunohistochemical Study of Endomyocardial Biopsy Specimens
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the mechanism of cardiac dysfunction in myocarditis, myoglobin, an intracellular oxygen-transport, was immunohistochemically examined in biopsy specimens obtained from the right side of the ventricular septum and left ventricular free wall in 58 patients with myocarditis and 19 controls. Sections 4 pm thick were stained by the indirect immunoperoxidase method using a polyclonal antibody to human myoglobin as the primary antibody. Under light microscopy, the intensity of myoglobin immunoreactivity in the tissue section was semiquantitatively classified from grade 0 to grade 3. Then, the grade of myoglobin staining was compared with clinical, hemodynamic and histopathologic parameters. In right and left ventricular specimens, the grade of myoglobin staining was positively correlated with ejection fraction, but inversely with left ventricular end-diastolic and end-systolic volume indices. The percentage of myocytes with grade 0 was correlated with the number of mononuclear cells in the specimens. In addition, the grade of myoglobin staining in right ventricular specimens was positively correlated with the duration of illness but inversely correlated with the number of mononuclear cells. In 4 patients who had serial biopsies, the ejection fraction was improved and the grade of myoglobin staining was in-creased in the convalescent stage. These results indicate that myoglobin staining reflects the intensity of myocarditis and a decrease of myoglobin may be important as one of the pathogenetic factors of cardiac dysfunction in myocarditis.
- 社団法人日本循環器学会の論文
- 1991-01-20
著者
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Fujiwara Takako
Kyoto Women's University
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Takahashi Masaaki
The Third Division Department Of Internal Medicine Kyoto University
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Kawai Chuichi
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Kawai Chuichi
京都大学 第3内科
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Kawai Chuichi
京都大学 医学研究科循環器内科学
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Matsuda Mitsuhiko
Department Of Internal Medicine Yamaguchi University
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Tanaka M
Osaka City Univ. Medical School
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Kawai C
The Japan Multicenter Investigation For Cardiovascular Diseases-b (jmic-b) Study Group
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Tanaka Masahiro
Rakuwakai Otowa Hospital
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MATSUMORI Akira
Third Division, Department of Internal Medicine, Kyoto University
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Kawai Chuichi
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Ueda Tadashi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Matsuda Mitsuo
The Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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FUJIWARA Hisayoshi
Third Division ,Department of Internal Medicine,Kyoto University
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Fujiwara Takako
Kyoto Women's University
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Kawamura Atsushi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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KIDA Mitsugu
The Third Division of Internal Medicine,Kyoto University
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HORIE KIYOSHI
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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MATSUDA MITSUO
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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ISHIDA MORIHARU
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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TAKEMURA GENZOU
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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KIDA MITSUGU
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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UEGAITO TAKASHI
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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TANAKA MASAHIRO
Third Division, Department of Internal Medicine, Faculty of Medicihe, Kyoto University
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Matsuda Mitsuo
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Kawai Chuichi
3rd Div. Dept Of Intern Med. Kyoto Univ
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Kida Mitsugu
The Third Division Of Internal Medicine Kyoto University
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Horie Kiyoshi
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Ishida Moriharu
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Matsuda Mitsuo
Third Division Department Of Internal Medicine And Pathology Kyoto University
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Kawai Chuichi
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Motai Michio
Section Of Technology Heiwa-bussan Co. Ltd.
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Uegaito Takashi
The Third Division Faculty Of Medicine Kyoto University
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Takashima Masayuki
Third Department Of Internal Medicine Kyoto University Faculty Of Medicine
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Tanaka Masaru
Department Of Cardiology Cardiovascular Center Osaka Red Cross Hospital
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Matsumori Akira
Third Division Department Of Internal Medicine Faculty Of Medicine Kyoto University
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Kida Mitsugu
Third Division Department Of Internal Medicine Faculty Of Medicihe Kyoto University
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Tanaka Makoto
Cardiovascular Center Osaka Red Cross Hospital
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Matsuda Mitsuo
Department Of Internal Medicine Yamaguchi University
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Kawamura Atsusi
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Kawamura Atsusi
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto Un
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Tanaka Masaru
Third Division Department Of Internal Medicine Kyoto University
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Takashima Masayuki
Cardiovascular Center Osaka Red Cross Hospital
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Ishida Moriharu
Department Of Cardiovascular Surgery And The Third Division Department Of Internal Medicine Kyoto University
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