FATE OF PORCINE AND HUMAN INSULIN AT THE SUBCUTANEOUS INJECTION SITE. I. DEGRADATION AND ABSORPTION OF INSULINS IN THE RAT
スポンサーリンク
概要
- 論文の詳細を見る
The plasma insulin and serum glucose levels were compared after the subcutaneous and intravenous administration of porcine and human insulin in rats. While no difference was observed in plasma insulin or serum glucose levels with either insulin after intravenous administration, the plasma insulin levels and hypoglycemic effects of human insulin were greater than those of porcine insulin after subcutaneous administration. At various time intervals, radioactivity in subcutaneous tissue was assayed for insulin and/or its metabolites by gel filtration. Using these data, the absorption and degradation rate constants of these substances were estimated according to a one-compartment model. The degradation rate constants of human insulin was approximately half of that for porcine insulin.
- 公益社団法人日本薬学会の論文
著者
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OKUMURA Katsuhiko
Department of Hospital Pharmacy, Kobe University School of Medicine
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HORI Ryohei
Department of Pharmacy, Kyoto University Hospital
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KOMADA Fusao
Department of Drug Informatics, Faculty of Pharmaceutical Sciences, Josai University
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HORI Ryohei
Pharmaceutical Research and Technology Institute
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Komada Fusao
Japan And Department Of Drug Informatics Faculty Of Pharmaceutical Sciences Jyosai University
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Komada Fusao
Department Of Pharmacy Kyoto University Hospital Faculty Of Medicine Kyoto University
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Okumura Katsuhiko
Department Of Clinical Evaluation Of Pharmacotherapy Kobe University Graduate School Of Medicine
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Komada F
Department Of Pharmacy Kobe University School Of Medicine
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Okumura K
Department Of Hospital Pharmacy School Of Medicine Kobe University
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