Protective Effect of N-Acyl Amino Acids (NAAs) on Cephaloridine (CER) Nephrotoxicity in Rabbits.
スポンサーリンク
概要
- 論文の詳細を見る
The protective effect of <I>N</I>-acyl amino acids (NAAs) against cephaloridine (CER)-induced nephrotoxicity was studied in rabbits. A large single intravenous dose of CER (more than 100 mg/kg) induced severe proximal tubular necrosis. Simultaneous treatment with several NAAs (at dosages of 100, 200 mg/kg, etc., i.v.), such as <I>N</I>-benzoyl-β-alanine (NBBA), <I>N</I>-benzoyl-6-aminocaproic acid, and <I>N</I>α, ε-dibenzoyl-D, L-lysine, remarkably suppressed the histopathological damage in the kidney induced by CER. NAAs have generally low toxicity in laboratory animals (e.g., the LD<SUB>50</SUB> of NBBA was more than 3, 000 mg/kg, i.v. in rats), and NAAs were suggested to be good candidates for reducing the nephrotoxicity of CER and other β-lactam antibiotics.
- 公益社団法人 日本薬理学会の論文
著者
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OKADA Ryuzo
Product Development Laboratories, Sankyo Co., Ltd.
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Okada Ryuzo
Product Development Laboratories Sankyo Co. Ltd.
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Kamiya Akira
Department Of Biomedical Engineering University Of Tokyo
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Kawahara Yukinori
Analytical And Metabolic Laboratories Sankyo Co. Ltd.
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Hori Ryohei
Department Of Hospital Pharmacy School Of Medicine Kobe University : Department Of Pharmacy Kyoto Un
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Inui Ken-ichi
Department of Hospital Pharmacy, School of Medicine, Tokyo Medical and Dental College
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Hirouchi Yasukuni
Product Development Laboratories, Sankyo Co., Ltd.
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Naganuma Hideo
Product Development Laboratories, Sankyo Co., Ltd.
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Kamiya Akira
Department of Hospital Pharmacy, School of Medicine, Yamaguchi University
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Kawahara Yukinori
Analytical and Metabolic Research Laboratories, Sankyo Co., Ltd.
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