Urinary Metabolites of Valproic Acid in Epileptic Patients

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概要

• 論文の詳細を見る

• The urinary excretion of valproic acid (VPA) and its metabolites (3-keto VPA, 3-OH VPA, and VPA-glucuronide) in 6 epileptic patients was studied using gas chromatography-mass spectrometry. The amount of VPA and 3-OH VPA excreted in the urine was low (0.1-0.5% of the dose of VPA and 0.6-1.5% of the dose of 3-OH administered). The amount of 3-keto VPA and glucuronide (VPA-Glu) excreted was marked (5.8-26.2% and 13.1-88.7% of the dose of VPA administered, respectively). The urinary excretion of VPA and its metabolites by patients who have taken a normal amount of a VPA preparation was almost the same as that of healthy volunteers. Two epileptic patients who took a large amount of the VPA preparation showed a high excretion of VPA-Glu without an increase in their plasma VPA-Glu.

• 社団法人日本薬学会の論文
• 1998-03-15

著者

• HAYASHI Takashi

  Department of Materials Science, Shonan Institute of Technology

• 渡辺 光男

  Hamamatsu Photonics K. K.

• KAMIYA Akira

  Department of Pharmacy, Yamaguchi University Hospital

• HISHINUMA TAKANORI

  Division of Pharmacotherapy, Graduate School of Pharmaceutical Sciences, Tohoku University

• Kamiya A

  Department Of Pharmacy Yamaguchi University Hospital

• Kamiya Akira

  Department Of Pharmacy Yamaguchi University Hospital

• YOSHIDA Hisahiro

  Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University

• Yoshida H

  Department Of Pharmacy Yamaguchi University Hospital

• Yoshida H

  Yamaguchi Univ. Hospital Yamaguchi Jpn

• Yoshida Hisahiro

  Department Of Drug Metabolism And Disposition Meiji Pharmaceutical University

• Watanabe M

  Faculty Of Pharmacy And Pharmaceutical Sciences Fukuyama University

• KIMOTO Hiroo

  Department of Pharmacy, Yamaguchi University Hospital

• KATAYAMA Hirokazu

  Fukuyama University, Faculty of Pharmacy and Pharmaceutical Sciences

• WATANABE Miki

  Fukuyama University, Faculty of Pharmacy and Pharmaceutical Sciences

• YOSHITOMI Hironori

  Fukuyama University, Faculty of Pharmacy and Pharmaceutical Sciences

• AKIMURA Tatsuo

  Neurosurgery, Yamaguchi University School of Medicine

• Kamiya Akira

  Department Of Biomedical Engineering University Of Tokyo

• Katayama H

  Fukuyama Univ. Hiroshima Jpn

• Hayashi T

  Department Of Pharmacy Fujita Health University Hospital

• Watanabe M

  Department Of Public Health Niigata College Of Medical Technology

• AKIYAMA Toshihiko

  Faculty of Pharmaceutical Sciences, Okayama University

• Akimura T

  Department Of Neurosurgery Yamaguchi University School Of Medicine

• Yoshitomi Hironori

  Fukuyama University Faculty Of Pharmacy And Pharmaceutical Sciences

• Akiyama T

  Faculty Of Pharmaceutical Sciences Okayama University

• Kimoto H

  Department Of Pharmacy Yamaguchi University Hospital

• Kimoto Hiroo

  Department Of Pathology Wakayama Medical College

• Katayama Hirokazu

  Fukuyama University Faculty Of Pharmacy And Pharmaceutical Sciences

• Hishinuma T

  Division Of Clinical Pharmacy Graduate School Of Pharmaceutical Sciences Tohoku University

• Hayashi Takashi

  Department Of Applied Chemistry Graduate School Of Engineering Osaka University

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