Adhesive Strength of Autologous Fibrin Glue
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概要
- 論文の詳細を見る
To establish an easy and rapid method for measuring the adhesive strength of fibrin glue and to clarify the factor(s) most affecting the strength, a study was made on the effect of the concentration of plasma components on the strength of cryoprecipitate (Cryo) prepared from a subject's own autologous plasma to be used as fibrin glue. The adhesive strength of the Cryo was measured with various supporting materials instead of animal skin using a tester of tension and compression. The results were as follows : (1) the strength of Cryo applied to ground flat glass (4cm^2) was significantly greater than that applied to clear glass, clear plastic, or smooth and flat wood chips; (2) the adhesive strength of Cryo depended on the concentration of thrombin with the optimal concentration being 50 units/ml; (3) the concentration of CaCl_2 did not affect the adhesive strength of Cryo; (4) the adhesive reaction was dependent on the temperature and the adhesive strength more quickly reached a steady state at 37℃ than at lower temperature; (5) the adhesive strength was correlated well with the total concentration of fibrinogen and fibronectin. These results indicate that the adhesive strengh of Cryo can be easily and quicky evaluated using a tester and ground glass with thrombin at 50 units/ml, and that the adhesive strength of Cryo can be predicted from the total concentration of fibrinogen and fibronoctin.
- 社団法人日本薬学会の論文
- 2000-03-01
著者
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KAMIYA Akira
Department of Pharmacy, Yamaguchi University Hospital
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Kamiya A
Department Of Pharmacy Yamaguchi University Hospital
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Kamiya Akira
Department Of Pharmacy Yamaguchi University Hospital
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YOSHIDA Hisahiro
Department of Drug Metabolism and Disposition, Meiji Pharmaceutical University
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Yoshida H
Department Of Pharmacy Yamaguchi University Hospital
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Yoshida H
Yamaguchi Univ. Hospital Yamaguchi Jpn
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Yoshida Hisahiro
Department Of Drug Metabolism And Disposition Meiji Pharmaceutical University
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HIROZANE Kiyoshi
Department of Pharmacy, Yamaguchi University Hospital
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Kamiya Akira
Department Of Biomedical Engineering University Of Tokyo
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Hirozane Kiyoshi
Department Of Pharmacy Yamaguchi University Hospital
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