Particulate and Microbial Contamination in In-Use Admixed Parenteral Nutrition Solutions(Biopharmacy)
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概要
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We evaluated particulate and microbial contamination in a total of 192 samples of in-use admixed and unadmixed parenteral nutrition solutions remaining in infusion bags in 10 hospitals. The mean numbers (range) of drug glass ampoules, plastic ampoules, and vials used in a total of 192 admixed solutions were 3.38 (1-13), 0.79 (0-7), and 1.2 (0-8), respectively. The mean number of particles (range) contained in the 192 samples according to the particle size (diameter) was 960.9 (30-9539)/ml for particles ≥1.3μm, 42.8 (0-587)/ml for those ≥5μm, 6.4 (0-146)/ml for those ≥10μm, and 0.09 (0-1)/ml for those ≥50μm. The number of particles ≥1.3μm in diameter was significantly higher in the 192 samples than in 7 samples (controls) of solutions not mixed with any ampoule or vial (p<0.0001). In addition, the number of particles ≥1.3μm in diameter was significantly higher in samples of solutions mixed with 4-13 glass ampoules than in those of solutions mixed with 1-3 glass ampoules (p<0.01). On the other hand, none of the 199 samples showed bacteria or fungi/5ml residual solution. Measures against particulate contamination of admixed parenteral nutrition solutions are necessary.
- 公益社団法人日本薬学会の論文
- 2005-12-01
著者
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Kamiya Akira
Yamaguchi Univ. Hospital Ube Jpn
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Oie Shigeharu
Yamaguchi Univ. Hospital Ube Jpn
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Oie Shigeharu
Department Of Pharmacy Yamaguchi University Hospital
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Kamiya Akira
Department Of Biomedical Engineering University Of Tokyo
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