Studies on Hospital Pharmaceutical Manufacturing (V) Preparation and Preliminary Clinical Evaluation of Serotonin Creatinin Sulfate Injection
スポンサーリンク
概要
- 論文の詳細を見る
Serotonin creatinine sulfate (5-HTCS) injection, one of our hospital pharmaceutical manufactured products, is used as a diagnostic reagent for small coronary resistance vessels. 5-HTCS injection was prepared in a clean room under sterile conditions. All lots of the 5-HTCS injections were checked for any foreign matter and particles, sterility, the presence of pyrogens and the content of 5-HTCS. The stability of 5-HTCS injections was investigated under various storage conditions. The remaining amount of 5-HTCS in the infusion solution was determined by spectrophotometry. The contents of 5-HTCS were unchanged for 6 months at -20℃ while kept in darkness and wrapped in foil. Under other storage conditions, at 5℃ in darkness, at room temperature (-5±0.5℃) in darkness wrapped in foil, at room temperature (25±0.5℃) under intense light (1000 Lux fluorescent light) and at 40℃ in darkness wrapped in foil, a considerable rise of the peak at 275 nm was observed. These results shows that the degradation of 5-HTCS in infusion solutions is temperature dependent and 5-HTCS Injections should thus be stored frozen and foil wrapped at -20℃ until the day of the use. Furthermore, the effect of 5-HTCS on small coronary resistance vessels differed from acetylcholine which had been already been used as a daily diagnostic tool. This suggests that a 5-HTCS injection may be an effective diagnostic tool for evaluating the small coronary resistance vessels' functional level that can not be evaluated by coronary angiography.
- 日本医療薬学会の論文
- 2000-02-10
著者
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Ohkawara Hiroshi
福島県立医科大学 循環器･血液内科
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Ohtani Hiroshi
Division Of Blood Transfusion And Transplantation Immunology Fukushima Medical University
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Ohto Hitoshi
Fukushima Medical Univ. Fukushima Jpn
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Ogata H
Pharmacy Fukushima Medical University Hospital
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Maruyama Yukio
The First Department Of Internal Medicine Tohoku University School Of Medicine
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Hoshi Masahiro
Pharmacy Fukushima Medical University Hospital
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Yoshida H
Department Of Pharmacy Yamaguchi University Hospital
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Yoshida H
Yamaguchi Univ. Hospital Yamaguchi Jpn
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Hirosaka Akira
NONSTOP group
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Hirosaka Akira
The First Department of Internal Medicine, Fukushima Medical University
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SAITO MOEMI
Pharmacy, Fukushima Medical University Hospital
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OGATA HIROSHI
Pharmacy, Fukushima Medical University Hospital
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MIKAWA TAKEHIKO
Pharmacy, Fukushima Medical University Hospital
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YOSHIDA HIROHIDE
Pharmacy, Fukushima Medical University Hospital
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KUROSAWA KAZUHIKO
The First Department of Internal Medicine, Fukushima Medical University
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EDO KIYOTO
Pharmacy, Fukushima Medical University Hospital
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Mikawa Takehiko
Pharmacy Fukushima Medical University Hospital
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Kurosawa Kazuhiko
The First Department Of Internal Medicine Fukushima Medical University
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Maruyama Yukio
The First Department Of Internal Medicine Fukushima Medical College
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Ogata Hiroshi
Pharmacy Fukushima Medical University Hospital
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Edo K
Department Of Pharmaceutical Sciences Tohoku University Hospital
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Edo Kiyoto
Pharmacy Fukushima Medical University Hospital
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Saito Moemi
Pharmacy Fukushima Medical University Hospital
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Hirosaka Akira
Center Ohta Nishinouchi Hospital Ohta General Hospital Foundation
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Hirosaka Akira
The First Department Of Internal Medicine Fukushima Medical University
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Maruyama Yukio
The First Department Internal Medicine Fukushima Medical College
-
Maruyama Yukio
The First Departmenr Of Internal Medicine Tohoku University School Of Medicine
-
Hirosaka Akira
First Department Of Internal Medicine Fukushima Medical College
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YOSHIDA Hirohide
Pharmacy, Frkushima Medical College Hospital
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