EFFECTS OF PROSTAGLANDINS ON EXCITATORY TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
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概要
- 論文の詳細を見る
Contractile response of the isolated canine tracheal muscle to transmural nerve stimulation was considerably depressed by 10<SUP>-6</SUP> g/ml of prostaglandin Al (PGA<SUB>1</SUB>), A<SUB>2</SUB> (PGA<SUB>2</SUB>), B<SUB>2</SUB> (PGB<SUB>2</SUB>), E<SUB>1</SUB> (PGE<SUB>1</SUB>), E<SUB>2</SUB> (PGE<SUB>2</SUB>) and F<SUB>2α</SUB> (PGF<SUB>2α</SUB>), while the response to exogenously administered ACh was only slightly affected by the pretreatment with prostaglandins (PGs). The order of the potency of the depressive effect was as follows; PGE<SUB>1</SUB>>PGE<SUB>2</SUB>>PGA<SUB>1</SUB>>PGA<SUB>2</SUB>≈PGB<SUB>2</SUB>≈PGF2<SUB>2α</SUB>. Therefore, if a negative feedback control mechanism through prostaglandins exists in the excitatory transmission in canine tracheal muscle, the PGE series may predominantly operate the mechanism. Indomethacin in a dose of 10<SUP>-6</SUP> g/ml produced a potentiation of the contractile responses to transmural nerve stimulation and to exogenously administered ACh.
- 社団法人 日本薬理学会の論文
著者
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YOSHIDA HIROHIDE
Pharmacy, Fukushima Medical University Hospital
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Nakahata Norimichi
Department Of Cellular Signaling And 21st Century Coe Program Graduate School Of Pharmaceutical Scie
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Nakanishi Hironori
Department Of Pharmacology Fukushima Medical College
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SUZUKI Takehiko
Department of Industrial Chemistry, Faculty of Technology, Tokyo Metropolitan University
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Suzuki Takehiko
Department Of Geography Tokyo Metropolitan University
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NAKAHATA Norimichi
Department of Pharmacology, Fukushima Medical College
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YOSHIDA Hirohide
Pharmacy, Frkushima Medical College Hospital
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SUZUKI Takehiko
Department of Pharmacology, Fukushima Medical College
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Suzuki Takehiko
Department of Chemistry, Nagoya University
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