INHIBITORY EFFECT OF TIARAMIDE ON AGGREGATION <I>IN VIVO</I> AND ON ELECTROPHORESIS OF RABBIT PLATELETS
スポンサーリンク
概要
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Effects of tiaramide, aspirin and indomethacin were studied on rabbit platelet aggregation in vivo and on platelet electrophoretic mobility. When tiaramide (6 mg/kg), aspirin (30 mg/kg) or indomethacin (1.3 mg/kg) was injected into the ear vein of rabbit during 60 sec, tiaramide only inhibited ADP-induced aggregation, 20 min after the injection. All three drugs prevented collagen-induced aggregation 20 and 120 min after the injection. Tiaramide and aspirin prevented aggregation 24 hours later. The inhibitory effects on the aggregation of tiaramide are presumably independent of prostaglandin synthesis, because malondialdehyde (a metabolite of PGG<SUB>2</SUB>) production was not influenced. Tiaramide reduced cyclic AMP levels in platelets after 20 min incubation, despite the ability of this agent to inhibit platelet aggregation. Tiaramide, aspirin and indomethacin <I>per se</I> has no effect on platelet electrophoretic mobility, while tiaramide prevented the decrease in the mobility produced by ADP. Tiaramide and aspirin also depressed the decrease in the mobility produced by collagen.
- 社団法人 日本薬理学会の論文
著者
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Takano Shizuko
Department of Pharmacology, Fukushima Medical University School of Medicine, Fukushima, 960-1295, Ja
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SUZUKI Takehiko
Department of Industrial Chemistry, Faculty of Technology, Tokyo Metropolitan University
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SAKURAI Kunio
Department of Pharmacology, Fukushima Medical College
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Suzuki Takehiko
Department Of Geography Tokyo Metropolitan University
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TAKANO Shizuko
Department of Pharmacology, Fukushima Medical College
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