INHIBITORY EFFECTS OF PROSTAGLANDIN E<SUB>1</SUB> AND E<SUB>2</SUB> ON CHOLINERGIC TRANSMISSION IN ISOLATED CANINE TRACHEAL MUSCLE
スポンサーリンク
概要
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The contractile response of the isolated canine tracheal muscle to the transmural nerve stimulation was depressed by atropine and augmented by physostigmine, indicating that the response was predominantly mediated via the parasympathetic nerve. The contractile response to the transmural nerve stimulation was inhibited by prostaglandin E<SUB>1</SUB> (PGE<SUB>1</SUB>) and E<SUB>2</SUB> (PGE<SUB>2</SUB>) (10<SUP>-7</SUP> to 10<SUP>-6</SUP> g/ml) and the inhibitory action of PGE<SUB>1</SUB> was more potent than that of PGE<SUB>2</SUB>. On the other hand, the contractile response of the tracheal muscle to exogenously administered ACh was unaffected by 10<SUP>-6</SUP> g/ml of PGE<SUB>1</SUB> and PGE<SUB>2</SUB>. These findings lend support to the hypothesis that the PGE series, in a manner similar to adrenergic transmission, are involved in a negative feed-back control mechanism for the transmitter release in cholinergic transmission.
- 社団法人 日本薬理学会の論文
著者
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Nakanishi Hironori
Department Of Pharmacology Fukushima Medical College
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SUZUKI Takehiko
Department of Industrial Chemistry, Faculty of Technology, Tokyo Metropolitan University
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YOSHIDA Hirohide
Department of Pharmacy, Fukushima Medical College Hospital
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Suzuki Takehiko
Department Of Geography Tokyo Metropolitan University
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Suzuki Takehiko
Department of Chemistry, Nagoya University
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